TRIAMTERENE AND HYDROCHLOROTHIAZIDE

Thiazide Diuretic

Brand names: Triamterene and Hydrochlorothiazide

Oral

Mechanism of Action

Thiazide Diuretic agent

Indications

patients on concomitant digitalis preparations

or with a history of cardiac arrhythmias

etc.). Triamterene and hydrochlorothiazide may be used alone or in combination with other antihypertensive drugs

such as beta-blockers. Since triamterene and hydrochlorothiazide may enhance the actions of these drugs

just as they are in the absence of pregnancy. Dependent edema in pregnancy

resulting from restriction of venous return by the expanded uterus

Contraindications

• amiloride hydrochloride or other formulations containing triamterene. Concomitant potassium supplementation in the form of medication
• potassium-containing salt substitute or potassium-enriched diets should also not be used. Impaired Renal Function: Triamterene and hydrochlorothiazide is contraindicated in patients with anuria

FDA Warnings

WARNINGS: Hyperkalemia: Abnormal elevation of serum potassium levels (greater than or equal to 5
Since uncorrected hyperkalemia may be fatal, serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide, when dosages are changed or with any illness that may influence renal function

Known Side Effects

12 documented side effects by frequency

Fatigue

1-10%

Drug Not Working

1-10%

Nausea

1-10%

Diarrhea

1-10%

Dizziness

1-10%

Shortness of Breath

1-10%

Headache

1-10%

Weakness

1-10%

Joint Pain

1-10%

Falls

0.1-1%

Limb Pain

0.1-1%

Itching

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Oral