TRIMETHOBENZAMIDE HYDROCHLORIDE

Electrolyte / Mineral

Brand names: Trimethobenzamide Hydrochloride

Oral

Mechanism of Action

12.1 Mechanism of Action The mechanism of action of trimethobenzamide as determined in animals is obscure, but may involve the chemoreceptor trigger zone (CTZ), an area in the medulla oblongata through which emetic impulses are conveyed to the vomiting center; direct impulses to the vomiting center apparently are not similarly inhibited. In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

Indications

8.4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Acute Dystonic Reactions and Other Extrapyramidal Symptoms (EPS) : Depending on the severity of symptoms, reduce the dosage or discontinue the drug
2 ) Masking of Other Serious Disorders : EPS and other CNS symptoms in patients treated with trimethobenzamide hydrochloride capsules may be confused with CNS signs of undiagnosed primary disease (e
If CNS symptoms occur, evaluate the risks and benefits of continuing trimethobenzamide hydrochloride capsules
The recent use of other drugs that cause CNS depression or EPS symptoms may also increase the risk; consider reducing the dosage or discontinuing the drug

Known Side Effects

10 documented side effects by frequency

Nausea

>10%

Drowsiness

>10%

Dizziness

1-10%

Vomiting

1-10%

Drug Not Working

1-10%

Fatigue

1-10%

Falls

0.1-1%

High Blood Pressure

0.1-1%

Weakness

0.1-1%

Excessive Sweating

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Oral