VILAZODONE HYDROCHLORIDE

Atypical Antidepressant

Brand names: VILAZODONE HYDROCHLORIDE

Oral

Mechanism of Action

12.1 Mechanism of Action The mechanism of action of vilazodone in the treatment of major depressive disorder is not fully understood, but is thought to be related to its enhancement of serotonergic activity in the CNS through selective inhibition of serotonin reuptake. Vilazodone is also a partial agonist at serotonergic 5-HT 1A receptors; however, the net result of this action on serotonergic transmission and its role in vilazodone’s antidepressant effect are unknown.

Indications

See full prescribing information

Contraindications

• 4 CONTRAINDICATIONS Vilazodone hydrochloride tablets are contraindicated in: • Patients taking
• or within 14 days of stopping
• monoamine oxidase inhibitors (MAOIs)
• including MAOIs such as linezolid or intravenous methylene blue
• because of an increased risk of serotonin syndrome [see Warnings and Precautions (5.2)

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents (e
• Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk (5
There was considerable variation in risk of suicidal thoughts and behaviors among drugs, but there was an increased risk identified in young patients for most drugs studied
There were differences in absolute risk of suicidal thoughts and behaviors across the different indications, with the highest incidence in patients with MDD

Known Side Effects

12 documented side effects by frequency

Diarrhea

1-10%

Nausea

1-10%

Anxiety

1-10%

Insomnia

1-10%

Drug Not Working

1-10%

Headache

1-10%

Depression

1-10%

Dizziness

1-10%

Fatigue

1-10%

Weight Gain

0.1-1%

Tingling/Numbness

0.1-1%

Vomiting

0.1-1%

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Compare With

7 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral