VINORELBINE

Other

Brand names: Vinorelbine

Intravenous

Mechanism of Action

12.1 Mechanism of Action Vinorelbine is a vinca alkaloid that interferes with microtubule assembly. The antitumor activity of vinorelbine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Vinorelbine may also interfere with: 1) amino acid, cyclic AMP and glutathione metabolism, 2) calmodulin-dependent Ca++-transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis. Vinorelbine inhibited mitotic microtubule formation in intact mouse embryo tectal plates at a concentration of 2 μM inducing a blockade of cells at metaphase, but produced depolymerization of axonal microtubules at a concentration 40 μM, suggesting a modest selectivity of vinorelbine for mitotic microtubules.

Indications

See full prescribing information

Contraindications

• 4 CONTRAINDICATIONS None None

FDA Warnings

5 WARNINGS AND PRECAUTIONS Hepatic Toxicity: Monitor hepatic function prior to initiation and during treatment ( 5
Advise females of reproductive potential of potential risk to the fetus and to use effective contraception ( 5
Death due to sepsis occurred in 1% of patients
3 Severe Constipation and Bowel Obstruction Severe and fatal paralytic ileus, constipation, intestinal obstruction, necrosis, and perforation occur in patients receiving vinorelbine

Known Side Effects

7 documented side effects by frequency

Drug Not Working

1-10%

Nausea

1-10%

Diarrhea

1-10%

Fatigue

1-10%

Vomiting

1-10%

Fever

0.1-1%

Shortness of Breath

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Intravenous