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Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare ALIROCUMAB (Praluent) and Evolocumab (Repatha) — clinical data, side effects, and patient experiences.
Praluent · PCSK9 Inhibitor
How it works
12.1 Mechanism of Action Alirocumab is a human monoclonal antibody that binds to proprotein convertase subtilisin kexin type 9 (PCSK9). PCSK9 binds to the low-density lipoprotein (...
Approved for
Repatha · PCSK9 Inhibitor
How it works
Human monoclonal antibody that binds to PCSK9, preventing LDL receptor degradation and increasing LDL-C clearance.
Approved for
Estimated frequency (%) based on clinical trial data
No specific warnings
Based on 12 Reddit discussions
ALIROCUMAB
0%
positive
8 threads
Evolocumab
0%
positive
4 threads
% of discussions mentioning each side effect
8 Reddit threads analysed for ALIROCUMAB
Overall Sentiment
Mixed
Comparison Threads
5
Avg Post Score
5 upvotes
Most discussed side effects in community
Threads directly comparing ALIROCUMAB to other medications
#111 Clinical Trials updated on 2021-07-28 All 111 studies in this list are **actively recruiting** at one or more locations. Most studies in this list **accept healthy volunteers** with the exception of any studies missing a 'Y' in the Healthy Volunteers column. Those studies may or may not be ac
#102 Clinical Trials updated on 2021-07-27 All 102 studies in this list are **actively recruiting** at one or more locations. Most studies in this list **accept healthy volunteers** with the exception of any studies missing a 'Y' in the Healthy Volunteers column. Those studies may or may not be ac
#54 Clinical Trials updated on 2021-07-19 All 54 studies in this list are **actively recruiting** at one or more locations. Most studies in this list **accept healthy volunteers** with the exception of any studies missing a 'Y' in the Healthy Volunteers column. Those studies may or may not be acce
#136 Clinical Trials updated on 2021-07-23 All 136 studies in this list are **actively recruiting** at one or more locations. Most studies in this list **accept healthy volunteers** with the exception of any studies missing a 'Y' in the Healthy Volunteers column. Those studies may or may not be ac
#74 Clinical Trials updated on 2021-07-22 All 74 studies in this list are **actively recruiting** at one or more locations. Most studies in this list **accept healthy volunteers** with the exception of any studies missing a 'Y' in the Healthy Volunteers column. Those studies may or may not be acce
Here are the links to the two abstracts in NEJM: [Alirocumab abstract](http://www.nejm.org/doi/full/10.1056/NEJMoa1501031) [Evolocumab abstract](http://www.nejm.org/doi/full/10.1056/NEJMoa1500858) I saw the evolocumab story on NBC Nightly News last night, and you know if I saw it, thousands upon tho
Does anyone know of any studied benefit in switching between evolocumab and alirocumab? If you’ve heard of/read any articles, please point me in that direction as well. TIA
# Enlicitid: Erster oraler PCSK9-Inhibitor – Game-Changer für Cholesterin-Therapie? Auf der AHA-Jahrestagung in New Orleans wurden gerade die Phase-3-Daten zu **Enlicitid (Enlicitide Decanoate, MK-0616)** von Merck/MSD vorgestellt. Falls ihr es nicht mitbekommen habt: Das könnte ein ziemlicher Durch
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
4 Reddit threads analysed for Evolocumab
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
11 upvotes
Most discussed side effects in community
Hi everyone, I’m an OBGYN SR 🙋♀️ seeking some practical guidance regarding Repatha (evolocumab) access in India for my father. He is a 64-year-old male who recently underwent left main coronary stenting and is currently on maximally tolerated medical therapy (rosuvastatin + ezetimibe + DAPT etc).
I've been diagnosed with 2 soft plaques (one in my heart at 35% stenosis and one in my right carotid at 45% stenosis) back in early July. Calcium score is 0. My cardiologist immediately put me on Rosuvastatin+Ezetimibe 20+10, Colchicine 1mg and Aspirin 100mg; I was taking them religiously for 8 week
About 8 weeks ago I (M, 50), started with 5mg Rosuvastatin due to an LDL cholesterol level of >160 and a scan of my neck vessels showing first signs of atherosclerosis. Before, I tried different diet changes, with no results larger than a 10% drop. After 4 weeks of just 5mg Rosuva my LDL came
Hi everyone, I’m an OBGYN SR 🙋♀️ seeking some practical guidance regarding Repatha (evolocumab) access in India for my father. He is a 64-year-old male who recently underwent left main coronary stenting and is currently on maximally tolerated medical therapy (rosuvastatin + ezetimibe + DAPT etc).
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
Both ALIROCUMAB and Evolocumab belong to the PCSK9 Inhibitor class. While they share a similar mechanism of action, differences in pharmacokinetics, dosing, and side effect profiles may make one more suitable than the other for individual patients. ALIROCUMAB is administered via Subcutaneous, whereas Evolocumab uses Oral. Route of administration can affect onset of action and patient adherence.
ALIROCUMAB carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.