What is Evolocumab used for?

Evolocumab (brand name Repatha) is a PCSK9 Inhibitor indicated for Hyperlipidemia, Familial Hypercholesterolemia, ASCVD.

What are the most common side effects of Evolocumab?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for Evolocumab. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is Evolocumab the same as Repatha?

Repatha is a brand name for Evolocumab. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

Evolocumab

Q: How does Evolocumab work?

Evolocumab works through the following mechanism: Human monoclonal antibody that binds to PCSK9, preventing LDL receptor degradation and increasing LDL-C clearance..

PCSK9 Inhibitor

Brand names: Repatha

Oral

Mechanism of Action

Human monoclonal antibody that binds to PCSK9, preventing LDL receptor degradation and increasing LDL-C clearance.

Indications

Hyperlipidemia

Familial Hypercholesterolemia

ASCVD

Known Side Effects

5 documented side effects by frequency

Injection Site Pain

1-10%

Back Pain

0.1-1%

Muscle Pain

0.1-1%

Joint Pain

0.1-1%

Fatigue

0.1-1%

Community Discussions

4 Reddit threads analysed for Evolocumab

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

11 upvotes

Most discussed side effects in community

Joint Pain (1)

Patient Experiences (r/pharmacy, r/AskDocs & more)

Help a fellow doctor out ✨

Hi everyone, I’m an OBGYN SR 🙋‍♀️ seeking some practical guidance regarding Repatha (evolocumab) access in India for my father. He is a 64-year-old male who recently underwent left main coronary stenting and is currently on maximally tolerated medical therapy (rosuvastatin + ezetimibe + DAPT etc).

r/indianmedschool1763mo ago

40M with 2 soft plaques, statin intolerance, and kinda freaking out

I've been diagnosed with 2 soft plaques (one in my heart at 35% stenosis and one in my right carotid at 45% stenosis) back in early July. Calcium score is 0. My cardiologist immediately put me on Rosuvastatin+Ezetimibe 20+10, Colchicine 1mg and Aspirin 100mg; I was taking them religiously for 8 week

r/Cholesterol10588mo ago

Dramatic drop of LDL with 5mg Rosuvastatin - but unbearable side effects

About 8 weeks ago I (M, 50), started with 5mg Rosuvastatin due to an LDL cholesterol level of >160 and a scan of my neck vessels showing first signs of atherosclerosis. Before, I tried different diet changes, with no results larger than a 10% drop. After 4 weeks of just 5mg Rosuva my LDL came

r/Cholesterol83111mo ago

Joint Pain

Help a fellow doctor out- repatha cost and access in India 🙈

r/DoctorsofIndia823mo ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → Evolocumab openFDA label JSON → Evolocumab FAERS adverse-event reports → Evolocumab ClinicalTrials.gov → completed Phase 2+ trials of Evolocumab

Compare With

10 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral