Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare BRIGATINIB (Alunbrig) and LORLATINIB (Lorbrena) — clinical data, side effects, and patient experiences.
Alunbrig · Targeted Cancer Therapy
How it works
12.1 Mechanism of Action Brigatinib is a tyrosine kinase inhibitor (TKI) with in vitro activity at clinically achievable concentrations against multiple kinases including ALK, ROS1...
Approved for
Lorbrena · Targeted Cancer Therapy
How it works
12.1 Mechanism of Action Lorlatinib is a kinase inhibitor with in vitro activity against ALK and ROS1 as well as TYK1, FER, FPS, TRKA, TRKB, TRKC, FAK, FAK2, and ACK. Lorlatinib de...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 13 Reddit discussions
BRIGATINIB
33%
positive
6 threads
LORLATINIB
43%
positive
7 threads
% of discussions mentioning each side effect
6 Reddit threads analysed for BRIGATINIB
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
3 upvotes
Most discussed side effects in community
Do you or your loved one have experience with Brigatinib (Alunbrig) for the first line treatment of ALK Positive NSCLC? Help Lung Cancer Canada provide insight by contacting us to share your experience and help lung cancer patients get access to this treatment. Email us at [email protected].
hey all 💗 it’s been a minute. my 16yo is in the sweet spot: highly concerning tumors have grown, but are not affecting function as of now. we’ve made the decision to start brigatinib in june, at the end of the school year. we have avastin on the back burner, trying to start with least “disruptive
My father, male, age 65, was diagnosed with Stage IV non-small cell lung cancer this past June. He has since undergone whole brain radiation and began taking the medication alectinib as his cancer contains an ALK mutation. After a couple of months, the alectinib caused terrible abdominal pain and hi
hi all ✨ sending everyone some love. also, long story short, my 15yo son has NF2, and has a slowly growing VS in the left; ss deaf from removal of fast-growing binuclear VS on the right. recent growth has sparked discussions of how to preserve his hearing. we have discussed avastin, and are also l
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
7 Reddit threads analysed for LORLATINIB
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
13 upvotes
Hey everyone, Long story short: I’m 27 and was recently diagnosed with stage 4 lung cancer ALK positive. It’s not curable, so I’ll be living with this for the rest of my life. I’m currently being treated at Memorial Sloan Kettering, and I’ll need to stay on a very specific (and very expensive) targe
HEADS UP THIS IS A LONG ONE!!! The past two years I’ve (27F) been dealing with severe breathing / wheezing problems. My PCP thought it was asthma, I was handed a pump and some montelukast. It continued and continued but I got used to it at a certain point and believed my doctor that it was just asth
Hello everyone, I’m writing as both a pulmonologist and a son. My mother has ALK-positive lung cancer, diagnosed in 2021. She has been on lorlatinib (Lorviqua) since March 2023, currently 50 mg daily, with an excellent and durable response, including complete response on recent scans. We are unfortu
I am a care partner for a 32 yr old Male who was just diagnosed with stage 4 NSCLC. Mets to liver, brain, bones (hip/spine) and lymph nodes. He got his ALK + diagnosis today and it was the first piece of ‘good news’ in weeks. His doctor has given him the option or Lorlatinib or a clinical study wher
A renowned oncologist specializing in targeted therapy and genetic treatment is now advising us to start **Lorlatinib** instead of **Lynparza** to treat my mom's (64F) pancreatic cancer with liver mets. Opposing what our current oncologist has advised us to do after we stopped chemo due to high bili
My dad has (60M) Stage IV NSCLC ALK+. Currently on Lorlatinib. It was effective for a bit but recent scans showed that the metastasized spots grew. Now, what are the alternative/ possible treatments to get it back under control? If anyone has any experience or thoughts, I would be very interested t
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
Both BRIGATINIB and LORLATINIB belong to the Targeted Cancer Therapy class. While they share a similar mechanism of action, differences in pharmacokinetics, dosing, and side effect profiles may make one more suitable than the other for individual patients.
Both medications are approved for 2.1 ). When two drugs treat the same condition, the choice between them often depends on the patient's medical history, other medications, tolerability, and prescriber preference.
BRIGATINIB carries 4 FDA warnings. LORLATINIB carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.