GEFITINIB vs LORLATINIB

Hi Everyone, My father has been recently diagnosed with non-small cell lung cancer (NSCLC) and his NGS full panel report confirmed an EGFR Exon 19 deletion mutation(no ALK, ROS1, or other actionable markers) We were told that this mutation is eligible for targeted therapy, and our oncologist has pre

Hi everyone, I’m posting here because I’m feeling overwhelmed and could really use some perspective and hope from people who understand what we’re going through. My 70-year-old grandmother was recently diagnosed with Stage IV lung adenocarcinoma. Her PET-CT shows a large tumor (around 15 cm) in the

Hi everyone, I’m posting here because my family and I are looking for some guidance, real-life experiences, and a bit of hope during a difficult time. My 70-year-old grandmother was recently diagnosed with Stage IV lung adenocarcinoma. Her PET-CT showed a right lung mass with mild spread to the medi

I am brand new to CRISPR/Cas9 and would be very appreciative of input on my experimental plan/design! For context, I want to manipulate 4 cancer-associated genes - APC, TP53, SMAD4, and KRAS - in colonic organoid cells. I will transfect cells when they are in a single-cell suspension during passagin

My dad was recently diagnosed with a stage 4 Non-Small Cell Lung Cancer (NSCLC) with detected brain metastases (MRI), sub-type is adenocarcinoma. Through DNA extraction, it was found that he has mutations on EGFR exon 18-20. His treatment is moving fast and he's currently undergoing oral chemo with

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Hey everyone, Long story short: I’m 27 and was recently diagnosed with stage 4 lung cancer ALK positive. It’s not curable, so I’ll be living with this for the rest of my life. I’m currently being treated at Memorial Sloan Kettering, and I’ll need to stay on a very specific (and very expensive) targe

HEADS UP THIS IS A LONG ONE!!! The past two years I’ve (27F) been dealing with severe breathing / wheezing problems. My PCP thought it was asthma, I was handed a pump and some montelukast. It continued and continued but I got used to it at a certain point and believed my doctor that it was just asth

Hello everyone, I’m writing as both a pulmonologist and a son. My mother has ALK-positive lung cancer, diagnosed in 2021. She has been on lorlatinib (Lorviqua) since March 2023, currently 50 mg daily, with an excellent and durable response, including complete response on recent scans. We are unfortu

I am a care partner for a 32 yr old Male who was just diagnosed with stage 4 NSCLC. Mets to liver, brain, bones (hip/spine) and lymph nodes. He got his ALK + diagnosis today and it was the first piece of ‘good news’ in weeks. His doctor has given him the option or Lorlatinib or a clinical study wher

A renowned oncologist specializing in targeted therapy and genetic treatment is now advising us to start **Lorlatinib** instead of **Lynparza** to treat my mom's (64F) pancreatic cancer with liver mets. Opposing what our current oncologist has advised us to do after we stopped chemo due to high bili

My dad has (60M) Stage IV NSCLC ALK+. Currently on Lorlatinib. It was effective for a bit but recent scans showed that the metastasized spots grew. Now, what are the alternative/ possible treatments to get it back under control? If anyone has any experience or thoughts, I would be very interested t