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Brand names: Gefitinib
12.1 Mechanism of Action The epidermal growth factor receptor (EGFR) is expressed on the cell surface of both normal and cancer cells and plays a role in the processes of cell growth and proliferation. Some EGFR activating mutations (exon 19 deletion or exon 21 point mutation L858R) within NSCLC cells have been identified as contributing to the promotion of tumor cell growth, blocking of apoptosis, increasing the production of angiogenic factors and facilitating the processes of metastasis. Gefitinib reversibly inhibits the kinase activity of wild-type and certain activating mutations of EGFR, preventing autophosphorylation of tyrosine residues associated with the receptor, thereby inhibiting further downstream signaling and blocking EGFR-dependent proliferation. Gefitinib binding affinity for EGFR exon 19 deletion or exon 21 point mutation L858R mutations is higher than its affinity for the wild-type EGFR. Gefitinib also inhibits IGF and PDGF-mediated signaling at clinically relevant
Contraindications
7 documented side effects by frequency
8 Reddit threads analysed for GEFITINIB
Overall Sentiment
Slightly positive
Comparison Threads
1
Avg Post Score
4 upvotes
Most discussed side effects in community
Threads directly comparing GEFITINIB to other medications
Hi Everyone, My father has been recently diagnosed with non-small cell lung cancer (NSCLC) and his NGS full panel report confirmed an EGFR Exon 19 deletion mutation(no ALK, ROS1, or other actionable markers) We were told that this mutation is eligible for targeted therapy, and our oncologist has pre
Hi everyone, I’m posting here because I’m feeling overwhelmed and could really use some perspective and hope from people who understand what we’re going through. My 70-year-old grandmother was recently diagnosed with Stage IV lung adenocarcinoma. Her PET-CT shows a large tumor (around 15 cm) in the
Hi everyone, I’m posting here because my family and I are looking for some guidance, real-life experiences, and a bit of hope during a difficult time. My 70-year-old grandmother was recently diagnosed with Stage IV lung adenocarcinoma. Her PET-CT showed a right lung mass with mild spread to the medi
I am brand new to CRISPR/Cas9 and would be very appreciative of input on my experimental plan/design! For context, I want to manipulate 4 cancer-associated genes - APC, TP53, SMAD4, and KRAS - in colonic organoid cells. I will transfect cells when they are in a single-cell suspension during passagin
My dad was recently diagnosed with a stage 4 Non-Small Cell Lung Cancer (NSCLC) with detected brain metastases (MRI), sub-type is adenocarcinoma. Through DNA extraction, it was found that he has mutations on EGFR exon 18-20. His treatment is moving fast and he's currently undergoing oral chemo with
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Company introduction Qianqiu Biological Technology Co., Limited Is a company mainly engaged in high quality pharmaceuticals, agricultural chemicals, pharmaceutical intermediates and other related products research and development and sales for the integration of high-tech enterprises. Analysis of te
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15 available comparisons
Dosage Forms
Tablet
Route
Oral