GEFITINIB vs NILOTINIB

Hi Everyone, My father has been recently diagnosed with non-small cell lung cancer (NSCLC) and his NGS full panel report confirmed an EGFR Exon 19 deletion mutation(no ALK, ROS1, or other actionable markers) We were told that this mutation is eligible for targeted therapy, and our oncologist has pre

Hi everyone, I’m posting here because I’m feeling overwhelmed and could really use some perspective and hope from people who understand what we’re going through. My 70-year-old grandmother was recently diagnosed with Stage IV lung adenocarcinoma. Her PET-CT shows a large tumor (around 15 cm) in the

Hi everyone, I’m posting here because my family and I are looking for some guidance, real-life experiences, and a bit of hope during a difficult time. My 70-year-old grandmother was recently diagnosed with Stage IV lung adenocarcinoma. Her PET-CT showed a right lung mass with mild spread to the medi

I am brand new to CRISPR/Cas9 and would be very appreciative of input on my experimental plan/design! For context, I want to manipulate 4 cancer-associated genes - APC, TP53, SMAD4, and KRAS - in colonic organoid cells. I will transfect cells when they are in a single-cell suspension during passagin

My dad was recently diagnosed with a stage 4 Non-Small Cell Lung Cancer (NSCLC) with detected brain metastases (MRI), sub-type is adenocarcinoma. Through DNA extraction, it was found that he has mutations on EGFR exon 18-20. His treatment is moving fast and he's currently undergoing oral chemo with

We could give you: 1. Best quality in your requirement 2. Competitive price in China market 3. mature Technical support 4. Professional logistic support 5 . Full experience of large numbers containers loading in Chinese sea port 6 Fast shipment by reputed shipping line 7. Packing with pallet as buye

Company introduction Qianqiu Biological Technology Co., Limited Is a company mainly engaged in high quality pharmaceuticals, agricultural chemicals, pharmaceutical intermediates and other related products research and development and sales for the integration of high-tech enterprises. Analysis of te

Just looking for some people who have been on either of these and their experiences! I started Dasatinib 100mg for my CML and it worked well for reducing my WBC and BCR-ABL. However, I was only on it for about 2 months as the side effects were pretty intolerable. Really severe bone pain, fatigue, he

Has anyone had any issues switching from brand to generic TKIs? Specifically Tasgina to Nilotinib. Counts have been good for a decade but now insurance making me change to Nilotinib. I know it’s basically the same med (just different fillers) but wanted to see if anyone had experience with it? Thank

Hi, the European Leukemia Net published its 2025 update of recommendations for the treatment of CML recently, you can find it on the internet ([2025 European LeukemiaNet recommendations for the management of chronic myeloid leukemia | Leukemia](https://www.nature.com/articles/s41375-025-02664-w)). T

Hey everyone, I’m 10 months into a chronic phase CML diagnosis with no detectable mutation. I started on Nilotinib, then moved to Dasatinib (up to 140mg), but my BCR’s been stuck around 20% and hasn’t dropped enough. Starting Ponatinib on Monday. If that doesn’t work, the plan is Asciminib, then tra

Hi guys, My husband has been living with CML for around 20 years now (age 36). He had been on Imatinib fot a long time, before he got changed on Nilotinib in 2020. Since he changed medication, his blood tests had always been stable (grade 4 or 4.5) until a few months ago, where he suddenly got to g

I'm about 6 months post diagnosis, and 4 months into TKIs (Tasigna 600mg daily). Super grateful to be TKI sensitive, with BCR-ABL1 down from 41% to .0066%, but now starting to process what life will be like living with CML and nilotinib. Fatigue and dry, itchy skin have been the main side effects so

Hello! Diagnosed with CML July 2024 and been taking Imatinib. However, for the past 6 months my CBC is not normal. My doctor decided to change tki to Nilotinib 600mg. Anyone who uses Nilotinib? It it better? My I know the side effects that you experience? Thank you 🙂

I’m 25 yo male diagnosed w cp cml in dec 2022. Responded well to nilotinib for 4 months with a hematologic relapse recently. Confirmed T315I mutation. Doc suggests ponatinib until we can schedule a bone marrow transplant. Anybody had similar experiences? What does my prognosis look like? Thanks for