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Brand names: nilotinib
12.1 Mechanism of Action Nilotinib is an inhibitor of the BCR-ABL kinase. Nilotinib binds to and stabilizes the inactive conformation of the kinase domain of ABL protein. In vitro , nilotinib inhibited BCR-ABL mediated proliferation of murine leukemic cell lines and human cell lines derived from patients with Ph+ CML. Under the conditions of the assays, nilotinib was able to overcome imatinib resistance resulting from BCR-ABL kinase mutations, in 32 out of 33 mutations tested. Nilotinib inhibited the autophosphorylation of the following kinases at IC50 values as indicated: BCR-ABL (20 to 60 nM), PDGFR (69 nM), c-KIT (210 nM), CSF-1R (125 to 250 nM), and DDR1 (3.7 nM).
Contraindications
13 documented side effects by frequency
8 Reddit threads analysed for NILOTINIB
Overall Sentiment
Mixed
Comparison Threads
2
Avg Post Score
15 upvotes
Most discussed side effects in community
Threads directly comparing NILOTINIB to other medications
Just looking for some people who have been on either of these and their experiences! I started Dasatinib 100mg for my CML and it worked well for reducing my WBC and BCR-ABL. However, I was only on it for about 2 months as the side effects were pretty intolerable. Really severe bone pain, fatigue, he
Has anyone had any issues switching from brand to generic TKIs? Specifically Tasgina to Nilotinib. Counts have been good for a decade but now insurance making me change to Nilotinib. I know it’s basically the same med (just different fillers) but wanted to see if anyone had experience with it? Thank
Hi, the European Leukemia Net published its 2025 update of recommendations for the treatment of CML recently, you can find it on the internet ([2025 European LeukemiaNet recommendations for the management of chronic myeloid leukemia | Leukemia](https://www.nature.com/articles/s41375-025-02664-w)). T
Hey everyone, I’m 10 months into a chronic phase CML diagnosis with no detectable mutation. I started on Nilotinib, then moved to Dasatinib (up to 140mg), but my BCR’s been stuck around 20% and hasn’t dropped enough. Starting Ponatinib on Monday. If that doesn’t work, the plan is Asciminib, then tra
Hi guys, My husband has been living with CML for around 20 years now (age 36). He had been on Imatinib fot a long time, before he got changed on Nilotinib in 2020. Since he changed medication, his blood tests had always been stable (grade 4 or 4.5) until a few months ago, where he suddenly got to g
I'm about 6 months post diagnosis, and 4 months into TKIs (Tasigna 600mg daily). Super grateful to be TKI sensitive, with BCR-ABL1 down from 41% to .0066%, but now starting to process what life will be like living with CML and nilotinib. Fatigue and dry, itchy skin have been the main side effects so
Hello! Diagnosed with CML July 2024 and been taking Imatinib. However, for the past 6 months my CBC is not normal. My doctor decided to change tki to Nilotinib 600mg. Anyone who uses Nilotinib? It it better? My I know the side effects that you experience? Thank you 🙂
I’m 25 yo male diagnosed w cp cml in dec 2022. Responded well to nilotinib for 4 months with a hematologic relapse recently. Confirmed T315I mutation. Doc suggests ponatinib until we can schedule a bone marrow transplant. Anybody had similar experiences? What does my prognosis look like? Thanks for
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 available comparisons
Dosage Forms
Tablet
Route
Oral