Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare BRODALUMAB (Siliq) and METHOTREXATE (METHOTREXATE) — clinical data, side effects, and patient experiences.
Siliq · Biologic (IL-17 Inhibitor)
How it works
12.1 Mechanism of Action Brodalumab is a human monoclonal IgG2 antibody that selectively binds to human IL-17RA and inhibits its interactions with cytokines IL-17A, IL-17F, IL-17C,...
Approved for
METHOTREXATE, Trexall, Otrexup · DMARD
How it works
12.1 Mechanism of Action Methotrexate inhibits dihydrofolic acid reductase. Dihydrofolates must be reduced to tetrahydrofolates by this enzyme before they can be utilized as carrie...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 22 Reddit discussions
BRODALUMAB
43%
positive
7 threads
METHOTREXATE
20%
positive
15 threads
% of discussions mentioning each side effect
7 Reddit threads analysed for BRODALUMAB
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
5 upvotes
Most discussed side effects in community
Earlier today I was browsing Reddit and stumbled [upon a post](http://www.reddit.com/r/AskReddit/comments/33ej71/disabled_people_of_reddit_what_is_something_we_do/cqkbwu7) It made me remember all I vowed to do if I ever managed rid myself of psoriasis. To this date I’ve not yet shared a whole lot
I'm currenlty engaged in a clinical trail for a new drug called "Brodalumab", am considering doing an AMA. Is there enough interest in this to warrant the AMA? My P had taken over 80-90% of my body and is now well under 5%. It has been a life changing experience and I want to tell others of the hope
Hello folks, Apologies if this is against the rules despite my reading them, I wanted to ask if folks have any experience with Leflunomide with treating psoriatic arthritis. I'm already on Brodalumab which has completely reversed the skin side but now at 35/36 I've started getting awful joint pains
Hello everyone, I've been dealing with psoriasis for about 9 years. I've tried Methotrexate and also Accutane. The latter helped significantly at first, but eventually stopped working. Now I'm supposed to start a medication called Kyntheum (active ingredient: Brodalumab). It's a biologic. Has anyon
Herein we explain how our novel data mining strategies for RNA-Seq datasets lead to new insights into the pathophysiology of psoraisis, an immune-mediated disease involving the skin. This story can also be found in [our recently published manuscript in JCI Insight.](https://insight.jci.org/articles/
I've been desperately looking into the 'cures,' making headway with recent science. As I've been going through an especially treacherous winter flare. It seems like stem cell therapies have made some profound headway in permanent remission of this disease, but unfortunately they are not legal treatm
Like the title says, I was supposed to start on Taltz but my doctor presumed that Siliq or Brodalumab would be best for me, He asked if I had any depression etc, I said I was never diagnosed but I do experience spells of depression as do anyone, I'm wondering if anyone here uses Siliq/Brodalumab an
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 Reddit threads analysed for METHOTREXATE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
125 upvotes
Most discussed side effects in community
Edit #3: I passed out today on my apartment steps out of absolutely the worst pain I’ve ever had in my life and someone saw me and called an ambulance. I finally got a diagnosis in the emergency room after bawling my eyes out of frustration at this entire situation and they found out I have a corona
This is going to be so, so, so long and I’m so sorry. But we don’t know what else to do. I’ve tried to compress it the best I could. 3f with medical mystery. First year of life: -couldn’t latch until 2 months old -refused all food, in all forms. -up every 20 minutes every single night, wouldn’t
Hey /r/pharmacy I'm a mod over on the /r/lupus sub and we got our [first report](https://www.reddit.com/r/lupus/comments/vt9owi/denied_my_methotrexate/) from a from an established user of the sub saying their methotrexate prescription has been denied due to the recent overturning of roe. This has [b
I've been dancing my heart out for the last couple days. In public. I don't know why I'm just happy to be alive and moving and I don't even need music. It is honestly so abnormal for me to be dancing that I figured I should ask here? Nothing bad comes from the urge to dance in public yeah? F19 5'4 1
https://www.oscn.net/dockets/GetCaseInformation.aspx?db=oklahoma&number=CF-2023-2233&cmid=4194257 Maybe fuzzy on details, but basically this case was a doc who ordered mtx for a patient and sent the order as qd vs qw. Pharmacist filled it. Patient died. Obviously very sad, we just normally
F23 just ran a 10k. For reference I use to be a big runner so I have pride but haven't ran in a few months so no foundation. Absolutely killed myself to PR today. The race was brutal with cramping in my legs and lower back. I have probably ran hundreds of races. NEVER before have I gotten so immedi
25F USA 130 lbs 5'6 Meds: Prednisone, Cymbalta, 5mg Percocet 3x a day I will appreciate any insight. I'm so frustrated and exhausted I can hardly think straight by this point. Typing this from a hospital bed, actually! I will try to provide how this affects me both physically and mentally, and my st
Be careful and vigilant when dealing with maverick prescribers. Look at this example, the dosage was flagged and followed up on yet dispensed regardless. https://www.theage.com.au/national/victoria/drug-for-common-skin-disorder-implicated-in-grandfather-s-death-20180206-p4yzik.html
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
BRODALUMAB is a Biologic (IL-17 Inhibitor), while METHOTREXATE belongs to the DMARD class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles. BRODALUMAB is administered via Subcutaneous, whereas METHOTREXATE uses Oral. Route of administration can affect onset of action and patient adherence.
Both medications are approved for See full prescribing information. When two drugs treat the same condition, the choice between them often depends on the patient's medical history, other medications, tolerability, and prescriber preference.
BRODALUMAB carries 4 FDA warnings. METHOTREXATE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.