Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare CENOBAMATE (Xcopri) and TOPIRAMATE (Topiramate) — clinical data, side effects, and patient experiences.
Xcopri, Xcopri Maintenance Pack, Xcopri Titration Pack · Anticonvulsant
How it works
12.1 Mechanism of Action The precise mechanism by which cenobamate exerts its therapeutic effects in patients with partial-onset seizures is unknown. Cenobamate has been demonstrat...
Approved for
Topiramate, Topamax · Anticonvulsant
How it works
12.1 Mechanism of Action The precise mechanisms by which topiramate exerts its anticonvulsant and preventive migraine effects are unknown; however, preclinical studies have reveale...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 25 Reddit discussions
CENOBAMATE
20%
positive
10 threads
TOPIRAMATE
20%
positive
15 threads
% of discussions mentioning each side effect
10 Reddit threads analysed for CENOBAMATE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
6 upvotes
Most discussed side effects in community
Hi, I was just hoping for some advice, or hearing if anyone else has had a similar experience, please? I have temporal lobe epilepsy, and take 250mg of Lamotrogine twice a day, 1.5g of Levetiracetam twice a day, and 200g of Cenobamate once a day. I have occasional seizures, maybe about 1 a week o
People often write here, with great specificity, about the the symptoms of their medication. I've tried lots of medicine over the years and apart from Keppra, which kind of wiped me out, I wouldn't say any have had really noticeable side-effects. I experience lots of the feelings that people write a
[first pic 16/6, second 9/9 and third is today] Hi everyone, I really need advice about my experience with isotretinoin (40mg daily) and how it might be interacting with my other medications. Here’s my situation: Current Medications: - Isotretinoin (Accutane): 40mg for acne - Ontozry (Cenobamate):
As well already know, many long covid patients who experience neurological symptoms have been found to have brain hypometabolism. Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837643/ https://www.sciencedirect.com/science/article/pii/S0306987723001822?via%3Dihub Easier to Read: https://www
This post is a bit long, I'm sorry. I basically just want to know about your experiences with Xcopri and maybe get some perspective or advice (I know, of course, that you most probably are not healthcare professionals). It used to be super complicated to have it be covered in my country but not anym
I wanted to share my experience because there is a lot of scary / negative stories online about Cenobamate. Before I started taking it I almost talked myself out of it after reading stories online. I had to go on it because I tried every other drug and nothing was working, my seizures got worse or I
Hi, I’m interested to know other people’s experiences regarding Cenobamate. I was seizure free for over two years until two days ago when I had a focal aware seizure. I’ve then had four more today, only lasting a few seconds each. I currently take 10mg of Clobazam at night but have tried Lamotrigine
Hi all! I’ve been seizure free for 5 months (typically 1 per 6 months for 5 years). I have strong side effects that began with the addition of Lamotrigine to Carbamazepine. We’ve been reducing the Lamotrigine to see if that helps, but it hasn’t. Has anyone any experience with this interaction? What
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 Reddit threads analysed for TOPIRAMATE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
21 upvotes
Most discussed side effects in community
# General Info An Anticonvulsant may be used as a mood stabilizer to treat mood disorders characterized by intense and sustained mood shifts, typically Bipolar Disorder. Mood stabilizers suppress swings between mania and depression. The oldest and most studied mood stabilizer is [Lithium](https://ww
Hi all, I know this is a common question/topic of discussion here but I’m so frustrated and I’m looking for any help. I’m currently on 1200 lithium and 150 lamictal. Started 50 topiramate once a night 3 1/2 weeks ago, have seen no results, no change in appetite, nothing. I was diagnosed a year ago
So my husband turned 28 today. It's his first birthday since we got married, his first birthday in years when all our friends can hang out, he has the day off, we have our own place, and generally everything is good. Only problem is that this morning I woke up with my mania coming to a screeching ha
Hi everyone, if you’re reading this, thank you. From the deepest I can, I appreciate you. I ***finally*** got my diagnosis on the 30th of September after many years of confusion, seeing multiple counselors, therapists, doctors and psychiatrists. Earlier in the month I voluntarily spent a week in th
Hey all! I started noticing significant shedding of my hair about six months after upping my dose of topiramate to 75 mg/day. It seemed to get worse when I switched generic brands to Teva and right now about 2/3 of my hair is gone. Literally clumps were falling out on my floors and I was cleaning
It’s a mixture of bad choices influenced by a depression episode and reasons out of my control. I was fit last summer during a hypomanic episode then I went through a following depression episode last fall/winter and gained 30lb through binge eating. Hovered there. Then got meds adjusted to change t
As of late I have found it very hard to get out of the house. I can get up, shower, eat but when it finally comes time to leave; I just can’t. Going to the store is no problem, but getting out to go do something is seemingly impossible. I’ve recently went under some pretty drastic medication changes
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
Both CENOBAMATE and TOPIRAMATE belong to the Anticonvulsant class. While they share a similar mechanism of action, differences in pharmacokinetics, dosing, and side effect profiles may make one more suitable than the other for individual patients.
CENOBAMATE carries 4 FDA warnings. TOPIRAMATE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.