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Brand names: Topiramate, Topamax
12.1 Mechanism of Action The precise mechanisms by which topiramate exerts its anticonvulsant and preventive migraine effects are unknown; however, preclinical studies have revealed four properties that may contribute to topiramate's efficacy for epilepsy and the preventive treatment of migraine. Electrophysiological and biochemical evidence suggests that topiramate, at pharmacologically relevant concentrations, blocks voltage-dependent sodium channels, augments the activity of the neurotransmitter gamma-aminobutyrate at some subtypes of the GABA-A receptor, antagonizes the AMPA/kainate subtype of the glutamate receptor, and inhibits the carbonic anhydrase enzyme, particularly isozymes II and IV.
Contraindications
10 documented side effects by frequency
15 Reddit threads analysed for TOPIRAMATE
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Most discussed side effects in community
# General Info An Anticonvulsant may be used as a mood stabilizer to treat mood disorders characterized by intense and sustained mood shifts, typically Bipolar Disorder. Mood stabilizers suppress swings between mania and depression. The oldest and most studied mood stabilizer is [Lithium](https://ww
Hi all, I know this is a common question/topic of discussion here but I’m so frustrated and I’m looking for any help. I’m currently on 1200 lithium and 150 lamictal. Started 50 topiramate once a night 3 1/2 weeks ago, have seen no results, no change in appetite, nothing. I was diagnosed a year ago
So my husband turned 28 today. It's his first birthday since we got married, his first birthday in years when all our friends can hang out, he has the day off, we have our own place, and generally everything is good. Only problem is that this morning I woke up with my mania coming to a screeching ha
Hi everyone, if you’re reading this, thank you. From the deepest I can, I appreciate you. I ***finally*** got my diagnosis on the 30th of September after many years of confusion, seeing multiple counselors, therapists, doctors and psychiatrists. Earlier in the month I voluntarily spent a week in th
Hey all! I started noticing significant shedding of my hair about six months after upping my dose of topiramate to 75 mg/day. It seemed to get worse when I switched generic brands to Teva and right now about 2/3 of my hair is gone. Literally clumps were falling out on my floors and I was cleaning
It’s a mixture of bad choices influenced by a depression episode and reasons out of my control. I was fit last summer during a hypomanic episode then I went through a following depression episode last fall/winter and gained 30lb through binge eating. Hovered there. Then got meds adjusted to change t
As of late I have found it very hard to get out of the house. I can get up, shower, eat but when it finally comes time to leave; I just can’t. Going to the store is no problem, but getting out to go do something is seemingly impossible. I’ve recently went under some pretty drastic medication changes
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26 available comparisons
Dosage Forms
Tablet
Route
Oral