Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare DESVENLAFAXINE (Desvenlafaxine) and DULOXETINE (DULOXETINE HYDROCHLORIDE) — clinical data, side effects, and patient experiences.
Desvenlafaxine, Pristiq · SNRI
How it works
12.1 Mechanism of Action The exact mechanism of the antidepressant action of desvenlafaxine is unknown, but is thought to be related to the potentiation of serotonin and norepineph...
Approved for
DULOXETINE HYDROCHLORIDE, Cymbalta · SNRI
How it works
12.1 Mechanism of Action Although the exact mechanisms of the antidepressant, central pain inhibitory and anxiolytic actions of duloxetine in humans are unknown, these actions are ...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 29 Reddit discussions
DESVENLAFAXINE
21%
positive
14 threads
DULOXETINE
27%
positive
15 threads
% of discussions mentioning each side effect
14 Reddit threads analysed for DESVENLAFAXINE
Overall Sentiment
Mixed
Comparison Threads
1
Avg Post Score
143 upvotes
Most discussed side effects in community
Threads directly comparing DESVENLAFAXINE to other medications
I’ve been doing some reading about the 2 available forms of desvenlafaxine, but I think I’ve confused myself at this point. Other than the salt form, is there any major difference between the two? When looking at FDA orange book online, Desvenlafaxine ER succinate has an AB rating to Desvenlafaxine
I have been dealing with mysterious tachycardia and heart palpitations for almost a decade. I have no genetic or lifestyle flags for heart issues, and basically have just been told I should try more cardio and cut out the caffeine. For reference, my usual resting heart rate hangs around 95-105bpm. T
EDIT: Thank you so much to everyone who replied to this post I really appreciate all the inputs, you guys are seriously more helpful then some doctors I have seen. I've got a lot more to think about in terms of what my issues could be caused by including POTS which I think is a real possibility, ADH
I'm a [20M] 6'3 238 lbs I dont smoke tobacco, I do smoke pot, I'm on desvenlafaxine and. Amitriptyline. and an hour ago I accidentally inhaled my water bottle cap, it went down my throat easily and now an hour and a half later I'm gassy and bloated and feel overall icky, should I go to the ER? Shou
I cannot find anything about mechanism pointing towards the uniqueness of duloxetine over venlafaxine or desvenlafaxine.
Subject of post (my gf- she is too anxious about this to post for herself) is 38 female, 5'2, 240lbs approx, takes methimazol, famotidine, adderall, desvenlafaxine, vit d. Just got off seroquel that she had been on for years. She suffers from MS, adhd, major depression, asthma, bipolar 1, and season
About a month ago I (19F) was prescribed Buspirone for anxiety and Desvenlafaxine for depression. These medications were chosen after I took a Genesight test and the results showed them to be among the best options. The person that prescribed them was not my usual consultant, but was the person I wa
I am a pharmacy technician with over 20 years of experience across just about every faction of pharmacy besides Big Pharma/R&D. I currently have a full time job in RX finance, and an evening gig in LTC data entry. The other day at my part time shop, I literally happened upon a script by chance
I (29F) learned in another Reddit thread that Miralax is derived from polyethylene glycol, a petroleum-based compound, derived from petroleum byproducts. This information obviously freaks me out. All of my medications have constipation/hard bowel movements as a side effect (Desvenlafaxine, clonidin
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 Reddit threads analysed for DULOXETINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
43 upvotes
Most discussed side effects in community
I am a 28 year old man and I've just realized that nothing interests me. I believe that it might be connected to depression as I am on medication for depression and anxiety (duloxetine) I am not really sad or anything. I am just very neutral. Things that used to interest, excite me and make me happ
I have been recovering from over a decade of major depressive disorder and recently diagnosed bipolar II. I’m seeing light at the end of the tunnel with Lamotrigine and lifestyle changes, and after several mental health evaluations, my psychiatrist gave me the best news ever; I can stop taking antid
Hi, just wondering if this is a common experience: So i've been taking agomelatine 50mg for about 5 months and duloxetine 60mg for 3 months now for severe depression and anxiety. The antidepressants have been working just as intended in the sense that most of the mental agony has gone, but there's
I ( M23) have been taking duloxetine 60 mg for 2 years now. While it has helped tremendously with my anxiety/depression/DPDR, it did cause sexual side effects for me. (I also take lamotrigine, but that is unlikely to cause effects like this) For me, these sides were very annoying; my main problem wa
Entry time 8:55am Before I went to sleep last night, I had nurses come 2 times, around 9:30pm and then at 10:40pm asking if I wanted to take some anxiety medication to help me sleep better. I refused both times as it wasn't initially prescribed, and in general I don't have a problem sleeping. My al
UHC is canceling coverage of my medication: Lamotrigine, Atomoxetine, and Duloxetine. Starts in January. Im barely getting by as it is. I need to find new insurance asap (Im in the USA). Its no wonder they were targeted. I just learned that they deny the most coverage of any US health insurer. Wtf a
Since the late of 2019 year, till now I've tried: 1- Escitalopram "Lexapro" (tried Atomoxetine "Strattera" with it, then stopped it due to its bad effects) (tried Risperidone "Rispardal" then stopped it, it hasn't only bad effects, but also highly increased prolactin) 2- Fluoxetine "Prozac" 3- Bupro
You know how a lot of sources say working towards a goal and then achieving it gives a sense of reward via dopamine? This week I got a pay rise, achieved a fitness goal I've been working towards for months and even got asked out on a date by someone quite attractive. But I feel absolutely nothing.
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
Both DESVENLAFAXINE and DULOXETINE belong to the SNRI class. While they share a similar mechanism of action, differences in pharmacokinetics, dosing, and side effect profiles may make one more suitable than the other for individual patients.
Both medications are approved for See full prescribing information. When two drugs treat the same condition, the choice between them often depends on the patient's medical history, other medications, tolerability, and prescriber preference.
DESVENLAFAXINE carries 4 FDA warnings. DULOXETINE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.