Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare DULOXETINE (DULOXETINE HYDROCHLORIDE) and VENLAFAXINE (Venlafaxine) — clinical data, side effects, and patient experiences.
DULOXETINE HYDROCHLORIDE, Cymbalta · SNRI
How it works
12.1 Mechanism of Action Although the exact mechanisms of the antidepressant, central pain inhibitory and anxiolytic actions of duloxetine in humans are unknown, these actions are ...
Approved for
Venlafaxine, Effexor · SNRI
How it works
Pharmacodynamics The mechanism of the antidepressant action of venlafaxine in humans is believed to be associated with its potentiation of neurotransmitter activity in the CNS. Pre...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 28 Reddit discussions
DULOXETINE
27%
positive
15 threads
VENLAFAXINE
62%
positive
13 threads
% of discussions mentioning each side effect
15 Reddit threads analysed for DULOXETINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
43 upvotes
Most discussed side effects in community
I am a 28 year old man and I've just realized that nothing interests me. I believe that it might be connected to depression as I am on medication for depression and anxiety (duloxetine) I am not really sad or anything. I am just very neutral. Things that used to interest, excite me and make me happ
I have been recovering from over a decade of major depressive disorder and recently diagnosed bipolar II. I’m seeing light at the end of the tunnel with Lamotrigine and lifestyle changes, and after several mental health evaluations, my psychiatrist gave me the best news ever; I can stop taking antid
Hi, just wondering if this is a common experience: So i've been taking agomelatine 50mg for about 5 months and duloxetine 60mg for 3 months now for severe depression and anxiety. The antidepressants have been working just as intended in the sense that most of the mental agony has gone, but there's
I ( M23) have been taking duloxetine 60 mg for 2 years now. While it has helped tremendously with my anxiety/depression/DPDR, it did cause sexual side effects for me. (I also take lamotrigine, but that is unlikely to cause effects like this) For me, these sides were very annoying; my main problem wa
Entry time 8:55am Before I went to sleep last night, I had nurses come 2 times, around 9:30pm and then at 10:40pm asking if I wanted to take some anxiety medication to help me sleep better. I refused both times as it wasn't initially prescribed, and in general I don't have a problem sleeping. My al
UHC is canceling coverage of my medication: Lamotrigine, Atomoxetine, and Duloxetine. Starts in January. Im barely getting by as it is. I need to find new insurance asap (Im in the USA). Its no wonder they were targeted. I just learned that they deny the most coverage of any US health insurer. Wtf a
Since the late of 2019 year, till now I've tried: 1- Escitalopram "Lexapro" (tried Atomoxetine "Strattera" with it, then stopped it due to its bad effects) (tried Risperidone "Rispardal" then stopped it, it hasn't only bad effects, but also highly increased prolactin) 2- Fluoxetine "Prozac" 3- Bupro
You know how a lot of sources say working towards a goal and then achieving it gives a sense of reward via dopamine? This week I got a pay rise, achieved a fitness goal I've been working towards for months and even got asked out on a date by someone quite attractive. But I feel absolutely nothing.
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
13 Reddit threads analysed for VENLAFAXINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
69 upvotes
Most discussed side effects in community
I just needed to vent about my depression and my issues with society's stance on it somewhere. I thought these were supposed to be the best years of my life? I'm not ugly, and I like to think I'm funny and friendly, so why don't people like me? I'm always alone. Always, always, always. I've spent my
Chronic fatigue. I feel so so tired and weak all the time. Brain fog so bad it is even hard to read and comprehend stuff. Insomnia. I have to take strong sedatives to sleep. I feel like death after waking up. Developed bruxism in my sleep. Noticed it only after it fvcked up all my teeth and they s
Hi all, I unfortunately, went through a tough antidepressant withdrawal from Venlafaxine, and after finding out how common the issue was I decided to get started on creating an application to help. The app is simple and just allows you to keep track of your symptoms as they come, so you can identify
*This is more of a rant than anything. I'm sorry for the formatting. I am on mobile and not really able to think clearly right now*   One month ago, I was put in a psych ward by my parents (I'm still a minor) during what was one of the worst depressive episodes I have ever had. I was physic
I am at the end of my rope right now, and I have nowhere else to go except jump. I wake up every morning wishing it would all stop, and it's my last thought before falling asleep. I am finishing up my PhD this year, but I don't have nearly the job prospects I was expecting. I am in a field as a m
*This is a super long post*, but before I started my AD I was looking for something detailed like this to see people's progressions on their meds. I had a hard time finding much, and this is why I decided to track my own progress and share after 6 weeks. Backstory: 26yr F, have had anxiety and mild
I take Venlafaxine. Just increased from 75 mg to 150 mg. I used to masturbate a lot. Not everyday...but most days. Now I have absolutely zero urge to. I’m talking to a girl now and she says that she’s a “freak” sexually. But I’m basically asexual now because of my meds. So of course.
Hi, Reddit, Over the past month, I have been weaning off of Venlafaxine, I was only on it for 3 months but it has been a debilitating experience that should be taken seriously! After a lot of research, I have noticed many people have been taking these medications for years and the withdrawal symptom
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
Both DULOXETINE and VENLAFAXINE belong to the SNRI class. While they share a similar mechanism of action, differences in pharmacokinetics, dosing, and side effect profiles may make one more suitable than the other for individual patients.
DULOXETINE carries 4 FDA warnings. VENLAFAXINE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.