Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare Deucravacitinib (Sotyktu) and GUSELKUMAB (TREMFYA) — clinical data, side effects, and patient experiences.
Sotyktu · TYK2 Inhibitor
How it works
Selective allosteric inhibitor of tyrosine kinase 2 (TYK2), blocking IL-23, IL-12, and Type I interferon signalling.
Approved for
TREMFYA, Tremfya · Biologic (IL-23 Inhibitor)
How it works
12.1 Mechanism of Action Guselkumab is a human monoclonal IgG1λ antibody that selectively binds to the p19 subunit of interleukin 23 (IL-23) and inhibits its interaction with the I...
Approved for
Estimated frequency (%) based on clinical trial data
No specific warnings
Based on 20 Reddit discussions
Deucravacitinib
40%
positive
5 threads
GUSELKUMAB
27%
positive
15 threads
% of discussions mentioning each side effect
5 Reddit threads analysed for Deucravacitinib
Overall Sentiment
Slightly positive
Comparison Threads
0
Avg Post Score
6 upvotes
Most discussed side effects in community
NEW YORK — Potential upcoming approvals of JAK inhibitors for hidradenitis suppurativa (HS) and vitiligo suggest these drugs are becoming one of the most versatile therapies in dermatology, and their safety for treating skin diseases might be a story of its own. For dermatologic indications, all JAK
Making this post to gather all the experiences with new medicines (and even traditionals if positive) that are currently being used for various type of scarring alopecias, these being: ***Biological medicines*** 1. **Adalimumab** / Humira 2. **Secukinumab** / Cosentyx 3. **IL-23** / Guselkumab ***Im
Anyone in NYS or anyone working in NYS Independent pharmacies know how to order Sotyktu? I tried ordering through Kinray and it's listed as "Special Order". I called Bristol Myers and they stated Cardinal Health Specialty Distribution are authorized to sell the product. I contacted Kinray (Cardinal
Living with psoriasis was always a daily struggle for me. The constant flare-ups, the unbearable itching, and the visible patches on my skin—psoriasis wasn’t just uncomfortable, it affected my confidence and how I felt about myself. Over the years, I tried countless treatments, from creams to light
This community is dedicated to sharing experiences, insights, and support for those using Deucravacitinib in their journey to manage psoriasis. Whether you’ve been using this supplement for a while, are considering trying it, or just want to learn more, you’re in the right place. # What we’re all ab
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 Reddit threads analysed for GUSELKUMAB
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
29 upvotes
Most discussed side effects in community
It's not every day you find a promising pennystock before it pops, and if you've been looking for one then you're gonna want to read this. I've been wanting to write a definitive DD post for this stock for a while but haven't had the time until now. There's been a few good posts about it but none ha
Hi everyone, first, just want to thank everyone for sharing in this forum, for the courage to reveal and be vulnerable, for providing a sense of community and connection when its easy to feel alone in what we're struggling with, and for the encouragement and support. About me: 51yo male with recen
I use the biologic in the photo. My doctor gave me the first injection, and today I have to do the second injection by myself. I wanted to ask if you inject yourself? Is it easy? I
My gf has been prescribed to get Secukinumab (Scapho) for 5 weeks, then monthly after, and Guselkumab (Tremfya) once a month (afaik this is conditional to her response to Scapho in the first 4 weeks). She's being charged 32k for Secukinumab and 82k for Guselkumab per session. Are there any availabl
So..we don't exactly know for sure even whether the injection had a direct effect or was merely acting on the gut microbiome which then quenched the inflammation. # Compositional Alteration of Gut Microbiota in Psoriasis Treated with IL-23 and IL-17 Inhibitors [Yu-Huei Huang](https://pubmed.ncbi.nl
Hi All, I was able to join a clinical trial for Guselkumab and had my first dose 3-4 weeks ago. Just wondering if any of you had experienced an onset of Migraine as a side effect of the medicine? Also, maybe more acne? Thanks!
***EDIT: I am in the US. I have my next GI follow up to likely begin Tremfya on 10/7. I did my labs today for calprotectin, TB, HIV, CBC, CMP, Hepatitis, and TPMT activity. Hi everyone, I stopped into my GI today and got copies of my colonoscopy, biopsy, and follow-up visit note with my GI from las
I was diagnosed with Psoriasis last March 2024. 3 months later, I started Guselkumab (Tremfya). Since then, my skin really cleared up. No flares. I feel normal and back with my old self except that I have hyperpigmentation on some areas but not really a big problem. Been taking this biologic for 8 m
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
Deucravacitinib is a TYK2 Inhibitor, while GUSELKUMAB belongs to the Biologic (IL-23 Inhibitor) class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles. Deucravacitinib is administered via Oral, whereas GUSELKUMAB uses Subcutaneous or Intravenous. Route of administration can affect onset of action and patient adherence.
GUSELKUMAB carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.