Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare Naltrexone/Bupropion (Contrave) and ORLISTAT (Xenical) — clinical data, side effects, and patient experiences.
Contrave, Contrave Extended-Release · Weight Management
How it works
Combination of opioid antagonist (naltrexone) and norepinephrine-dopamine reuptake inhibitor (bupropion) that reduces appetite centrally.
Approved for
Xenical · Weight Management
How it works
12.1 Mechanism of Action Orlistat is a reversible inhibitor of gastrointestinal lipases. It exerts its therapeutic activity in the lumen of the stomach and small intestine by formi...
Approved for
Estimated frequency (%) based on clinical trial data
No data
No specific warnings
Based on 15 Reddit discussions
Naltrexone/Bupropion
25%
positive
8 threads
ORLISTAT
29%
positive
7 threads
% of discussions mentioning each side effect
8 Reddit threads analysed for Naltrexone/Bupropion
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
57 upvotes
Most discussed side effects in community
Attached is my current stack for my depression/disassociation. I’m looking for any recommendations for adding or subtracting. I’ve been dealing with this for 1.5 years and have no hx with mental illness prior. Sudden onset and chronic. I WILL find the reason and I WILL see myself through it. Anyone
I don't get it. If someone is taking Contrave (Bupropion/Naltrexone), they are told that opioids won't work for their pain due to the naltrexone. Yet if someone is taking Targin, how is the oxycodone part working for pain, when there is naloxone there too? Please explain it to me like I'm five, beca
Since it came up multiple times in the discussions on my last post (about the estimated QALY benefits of weight loss drugs), I figured I’d go over some details on what the current crop of non-shitty FDA-approved weight loss drugs look like, in terms of side effects, typical weight lost, and other fa
Hello all, I know this is a Hims sub, but there doesn’t seem to be a Hers equivalent and I’m just starting out the Hers version of the weightloss program and thought it would be helpful to make a post detailing all the things I wish I would have known myself when deciding to take the plunge. First
To whom it may concern, this is my experience taking **Hims - Weight Loss Subscription.** ​ **Subscribed to:** Medication Kit 1 (3 month supply) = $297.00 Bupropion XL Metformin XR Naltrexone + Topiramate + Vitamin B12 ​ **Days from approval to receiving medications:** 6 day
I am 28f 220 pounds 5’6”. My psychiatrist prescribed me bupropion and naltrexone separately (contrave) I’m going to be taking 150mg XL of bupropion and 25mg of naltrexone. I’m a little nervous about the side effects and was wondering if anyone else was prescribed these two pills separately for weigh
Hey everyone, I’ve been dealing with anhedonia and severe executive dysfunction since childhood (around age 10-12). Traditional medications—like stimulants, Vortioxetine, and Bupropion—have acted like literal sugar pills for me. Zero positive effects, zero side effects. It’s like my brain just does
Has anyone seen Naltrexone taking for weight loss(with bupropion) prescribed to a patient already taking a chronic opioid? I've seen other pharmacist verify this but I thought this combination was contraindicated.
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
7 Reddit threads analysed for ORLISTAT
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
267 upvotes
Most discussed side effects in community
I'm 20F, 5' 9" (175cm). SW255, CW140, GW140. So a couple of years ago my doctor suggested that I do a low-fat diet with 6-7 small 250cal meals per day, basing them on whole grains and some very lean protein with a fruit, and taking orlistat with meals that had more fat than usual. I tried that and f
I wanted to share my experience in case it helps anyone fighting with their insurance or pharmacy benefit manager (PBM) to get coverage for **Mounjaro or Zepbound**. I’m a **Massachusetts resident (47F, 5’6”) with a BMI of 37.1 in 9/2022**. I have **hypertension and moderate sleep apnea (AHI=15)**,
This sub has been a huge source of info. and comfort to me and I wanted to share my story in case it may help those considering Sema for weight loss: I started on Sema for "vanity" reasons. I have struggled with a borderline ED and body dysmorphia all my life, having grown up a as a dancer without
I read so much negative stuff about orlistat on this forum and elsewhere, and thought I should take time to share my experience. A lot people describe an uneasy feeling in their stomach when eating fat on orlistat. I do have *a *feeling too, but I don't think it's uncomfortable. I just feel... satia
Greetings, Long time lurker, v. rare poster. Came here because I was prescribed Orlistat, got the dreaded oily diarrhea, scoured the internet for answers to no avail and eventually found a solution myself. I reckon reddit is the best possible place to put this info for any other poor souls scourin
Hi everyone. I am mainly writing this for cathartic reasons. I have struggled with weight my entire life and I never feel like talking to my friends or tweeting about it quite captures my life. I welcome any comments, criticisms, or words of support. ​ TLDR: I'm a smart guy and have had s
Another struggling to lose weight with pcos post! I exercise regularly - bike to the gym in the morning, yoga or dance in my lunch break and some kind of activity at night like swimming or walking. My eating habits are pretty good - healthy home prepared meals. I try to be mindful of carbs and sug
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
Both Naltrexone/Bupropion and ORLISTAT belong to the Weight Management class. While they share a similar mechanism of action, differences in pharmacokinetics, dosing, and side effect profiles may make one more suitable than the other for individual patients.
ORLISTAT carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.