Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Brand names: ORENCIA
12.1 Mechanism of Action Abatacept, a selective costimulation modulator, inhibits T-cell (T lymphocyte) activation by binding to CD80 and CD86, thereby blocking interaction with CD28. This interaction provides a costimulatory signal necessary for full activation of T lymphocytes. Activated T lymphocytes are implicated in the pathogenesis of RA, pJIA and PsA and are found in the synovium of patients with RA, pJIA and PsA. In vitro , abatacept decreases T-cell proliferation and inhibits the production of the cytokines TNF alpha (TNFα), interferon-γ, and interleukin-2. In a rat collagen-induced arthritis model, abatacept suppresses inflammation, decreases anti-collagen antibody production, and reduces antigen specific production of interferon-γ. The relationship of these biological response markers to the mechanisms by which ORENCIA exerts its clinical effects is unknown.
Contraindications
5 documented side effects by frequency
10 Reddit threads analysed for ABATACEPT
Overall Sentiment
Mixed
Comparison Threads
7
Avg Post Score
6 upvotes
Most discussed side effects in community
Threads directly comparing ABATACEPT to other medications
Two studies demonstrated that 2 biologic drugs decreaed COVID-19 deaths: [https://www.medspoke.co/taps/6540](https://www.medspoke.co/taps/6540?fbclid=IwAR0JQufrsac0UV_fKtyFbUfyyWRJBiTEBjYp1mMdzpFhfbEvszsaOniFOSg) Though this was a study on rheumatoid arthritis patients, I have many patients on bi
I was encouraged to post this even though it is not specific, practical information because people might find it hopeful. So here goes, but don't ask me for more info because this is all I know: I have had RA for about decades and Sjogren's for at least 12 years with significant symptoms. I have I
What on earth is the model for naming new drugs? They sound like kids pointed at a list of syllables and picked the ones that sounded worst together, or someone's using a bad Tolkein name generator. I assume they include references to component materials or something, given that many have common syl
Hi everyone! I want to know y’all’s experience with different Infusion treatments for RA vs injections. I am currently on methotrexate but it’s giving me pretty bad nausea and anxiety and am wanting to switch! My doctor diagnosed me with palindromic pheumatism with a. Positive RA factor. Any posit
Has anyone found the injections worked better than the infusion? Ive done 3 months of infusions and my team think it only appeared to work because i was on steroids. Ive now finished steroids and the pain in constant so we are going to try the weekly injections.
29, Female, white, 30w pregnant, 6', 240lb. Also have lupus & rheumatoid arthritis (dx 2016) and I'm in a flare up of my anemia of chronic disease. Gallbladder removed in 2013. Non smoker, lots of meds including plaquenil, abatacept, sertraline, welbutrin. No change in meds since start of pregna
I was recently admitted to the hospital for GI problems and they ended up making an incidental finding on my liver: "Within the posterior segment of the right hepatic lobe is a low-attenuation hepatic lesion which measures 2 cm (image 3:47). This could be a cavernous hemangioma but this cannot be c
Hello guys! I’ve been recommended to ask this in here so… I’d like to know about Rheumatoid Arthritis and Orencia Abatacept (medicine) in Canada The thing is, I’d like to someone very important to me (25F, 5”1, ~130lbs) can come to Canada and stay with me, but she needs this medication and haven’t f
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
11 available comparisons
Dosage Forms
Tablet
Route
Intravenous, Subcutaneous