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Brand names: CIBINQO, Cibinqo
12.1 Mechanism of Action CIBINQO is a Janus kinase (JAK) inhibitor. Abrocitinib reversibly inhibits JAK1 by blocking the adenosine triphosphate (ATP) binding site. In a cell-free isolated enzyme assay, abrocitinib was selective for JAK1 over JAK2 (28-fold), JAK3 (>340-fold), and tyrosine kinase (TYK) 2 (43-fold), as well as the broader kinome. The relevance of inhibition of specific JAK enzymes to therapeutic effectiveness is not currently known. Both the parent compound and the active metabolites inhibit JAK1 activity in vitro with similar levels of selectivity.
Contraindications
8 documented side effects by frequency
15 Reddit threads analysed for ABROCITINIB
Overall Sentiment
Mixed
Comparison Threads
2
Avg Post Score
8 upvotes
Most discussed side effects in community
Threads directly comparing ABROCITINIB to other medications
Would someone please cross post to r/dyshidrosis. (they won't let me post because I am a professional researcher in the field). # Traditional Hand Eczema Treatments May Face Obsolescence Ted Bosworth December 18, 2024 [2]()[55]()Add to Email Alerts NEW YORK, NY — For immediate control of a hand ecz
# Traditional Hand Eczema Treatments May Face Obsolescence Ted Bosworth December 18, 2024 [2]()[55]()Add to Email Alerts NEW YORK, NY — For immediate control of a hand eczema flare, the old soak and smear approach with moisturizers or corticosteroids might live on, but they are moving to the back of
Recently started taking a new drug through a clinical trial called Abrocitinib (Made by Pfizer), it is an oral tablet once a day and from what my doctors have said it is comparable and even slightly more effective for people than Dupixent. I wanted to share my results, I have had severe eczema for 7
I've given a few updates on the trial I'm in for Abrocitinib over the past couple of years - thought I'd round it out now the trial is coming to an end. I think I last posted around the 18 month mark and said I felt the effects were wearing off and some mild eczema had returned. I'm happy to say th
I've had full body eczema since about 18 years old. I can't really remember what my skin was like before then. Managing my eczema has been such a big part of my adult life. But after 2 months on dupixent I feel like my skin has never been as smooth.. or as oily! It's honestly taking my brain a whil
Quick rant here! Because It’s getting annoying and frustrating that they always hype up the new drugs for eczema sufferers for example, the JAK inhibitors, and I’m so happy to read the results but they never want to discuss the adverse side effects. They always want to say it’s mild and that they’re
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20 available comparisons
Dosage Forms
Tablet
Route
Oral