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Compare ABROCITINIB (CIBINQO) and LORLATINIB (Lorbrena) — clinical data, side effects, and patient experiences.
CIBINQO, Cibinqo · JAK Inhibitor
How it works
12.1 Mechanism of Action CIBINQO is a Janus kinase (JAK) inhibitor. Abrocitinib reversibly inhibits JAK1 by blocking the adenosine triphosphate (ATP) binding site. In a cell-free i...
Approved for
Lorbrena · Targeted Cancer Therapy
How it works
12.1 Mechanism of Action Lorlatinib is a kinase inhibitor with in vitro activity against ALK and ROS1 as well as TYK1, FER, FPS, TRKA, TRKB, TRKC, FAK, FAK2, and ACK. Lorlatinib de...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 22 Reddit discussions
ABROCITINIB
47%
positive
15 threads
LORLATINIB
43%
positive
7 threads
% of discussions mentioning each side effect
15 Reddit threads analysed for ABROCITINIB
Overall Sentiment
Mixed
Comparison Threads
2
Avg Post Score
8 upvotes
Most discussed side effects in community
Threads directly comparing ABROCITINIB to other medications
Would someone please cross post to r/dyshidrosis. (they won't let me post because I am a professional researcher in the field). # Traditional Hand Eczema Treatments May Face Obsolescence Ted Bosworth December 18, 2024 [2]()[55]()Add to Email Alerts NEW YORK, NY — For immediate control of a hand ecz
# Traditional Hand Eczema Treatments May Face Obsolescence Ted Bosworth December 18, 2024 [2]()[55]()Add to Email Alerts NEW YORK, NY — For immediate control of a hand eczema flare, the old soak and smear approach with moisturizers or corticosteroids might live on, but they are moving to the back of
Recently started taking a new drug through a clinical trial called Abrocitinib (Made by Pfizer), it is an oral tablet once a day and from what my doctors have said it is comparable and even slightly more effective for people than Dupixent. I wanted to share my results, I have had severe eczema for 7
I've given a few updates on the trial I'm in for Abrocitinib over the past couple of years - thought I'd round it out now the trial is coming to an end. I think I last posted around the 18 month mark and said I felt the effects were wearing off and some mild eczema had returned. I'm happy to say th
I've had full body eczema since about 18 years old. I can't really remember what my skin was like before then. Managing my eczema has been such a big part of my adult life. But after 2 months on dupixent I feel like my skin has never been as smooth.. or as oily! It's honestly taking my brain a whil
Quick rant here! Because It’s getting annoying and frustrating that they always hype up the new drugs for eczema sufferers for example, the JAK inhibitors, and I’m so happy to read the results but they never want to discuss the adverse side effects. They always want to say it’s mild and that they’re
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
7 Reddit threads analysed for LORLATINIB
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
13 upvotes
Hey everyone, Long story short: I’m 27 and was recently diagnosed with stage 4 lung cancer ALK positive. It’s not curable, so I’ll be living with this for the rest of my life. I’m currently being treated at Memorial Sloan Kettering, and I’ll need to stay on a very specific (and very expensive) targe
HEADS UP THIS IS A LONG ONE!!! The past two years I’ve (27F) been dealing with severe breathing / wheezing problems. My PCP thought it was asthma, I was handed a pump and some montelukast. It continued and continued but I got used to it at a certain point and believed my doctor that it was just asth
Hello everyone, I’m writing as both a pulmonologist and a son. My mother has ALK-positive lung cancer, diagnosed in 2021. She has been on lorlatinib (Lorviqua) since March 2023, currently 50 mg daily, with an excellent and durable response, including complete response on recent scans. We are unfortu
I am a care partner for a 32 yr old Male who was just diagnosed with stage 4 NSCLC. Mets to liver, brain, bones (hip/spine) and lymph nodes. He got his ALK + diagnosis today and it was the first piece of ‘good news’ in weeks. His doctor has given him the option or Lorlatinib or a clinical study wher
A renowned oncologist specializing in targeted therapy and genetic treatment is now advising us to start **Lorlatinib** instead of **Lynparza** to treat my mom's (64F) pancreatic cancer with liver mets. Opposing what our current oncologist has advised us to do after we stopped chemo due to high bili
My dad has (60M) Stage IV NSCLC ALK+. Currently on Lorlatinib. It was effective for a bit but recent scans showed that the metastasized spots grew. Now, what are the alternative/ possible treatments to get it back under control? If anyone has any experience or thoughts, I would be very interested t
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
ABROCITINIB is a JAK Inhibitor, while LORLATINIB belongs to the Targeted Cancer Therapy class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
ABROCITINIB carries 4 FDA warnings. LORLATINIB carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.