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Brand names: FARXIGA, Farxiga
12.1 Mechanism of Action Sodium-glucose cotransporter 2 (SGLT2), expressed in the proximal renal tubules, is responsible for the majority of the reabsorption of filtered glucose from the tubular lumen. Dapagliflozin is an inhibitor of SGLT2. By inhibiting SGLT2, dapagliflozin reduces reabsorption of filtered glucose and thereby promotes urinary glucose excretion. Dapagliflozin also reduces sodium reabsorption and increases the delivery of sodium to the distal tubule. This may influence several physiological functions including, but not restricted to, lowering both pre- and afterload of the heart and downregulation of sympathetic activity, and decreased intraglomerular pressure which is believed to be mediated by increased tubuloglomerular feedback.
Contraindications
9 documented side effects by frequency
15 Reddit threads analysed for DAPAGLIFLOZIN
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
14 upvotes
Most discussed side effects in community
I’m honestly so happy I’m not even sure how I feel. Back in July I unexpectedly found out I was diabetic after finding a high amount of sugar in my urine and being urged to go to the ER for immediate bloodwork. I’ve been put on 5mg of Farxiga (dapagliflozin) the last month or so and have been keepi
I used to take Xigduo and it was covered just fine on my previous insurance, but then I lost my job and had to get a plan off the healthcare marketplace. They have a fairly large deductible for prescriptions and charge coinsurance on name-brand drugs, so even after using a manufacturer's coupon I'd
http://www.fda.gov/Drugs/DrugSafety/ucm505860.htm The U.S. Food and Drug Administration (FDA) has strengthened the existing warning about the risk of acute kidney injury for the type 2 diabetes medicines canagliflozin (Invokana, Invokamet) and dapagliflozin (Farxiga, Xigduo XR). Based on recent repo
So I just got my first CGM and I'm loving it! Previously, I was finger pricking and noticed that my waking BG was always higher than it was the rest of the day. I suspected Dawn Phenomenon, as it would be 120 odd and then settle down to 80-90 throught the day, with the odd spike upt to 120-140 after
I am 34 F , I have put on weight ( 13 kgs or 30 pounds ) steadily over the last 3-4 years post covid. Current weight is 94kg or 207 pounds at 166cm height. My HB1AC is 6.4 which my doctor said is on the border. I have high LDL cholesterol at 214. HOMA IR is 3.6 so I have insulin sensitivity. My do
I know 6 days is a small window, but hear me out. Diabetic for 9 years. Maintained it below 7 till 6 months back. Met with accident on 6th Oct, thumb got amputated just below nail. Found out during surgery blood tests Hba1c was 8 ( stress and stress eating in last 6 months pushed it up). Surgeon s
Hi, my dad (58) was diagnosed with Type 2 diabetes almost a year ago. My dad drinks alcohol occasionally and is a non-smoker. Last December 6, 2024, his HbA1c increased from 7.5 to 8.1. We were a bit complacent with my dad's diet, and as a family of 5, we also had some lapses. We want to be stricter
Hi everyone, well I had a terrible year last year which brought on a huge amount of stress, due to mental health issues with my daughter and also working in a high pressured environment. I am a self-employed consultant so I have to work as I am the main breadwinner for the family. My diabetic contr
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23 available comparisons
Dosage Forms
Tablet
Route
Oral