FLUVASTATIN

Statin

Brand names: Fluvastatin, Lescol

Pregnancy: Category XOral

Mechanism of Action

12.1 Mechanism of Action Fluvastatin sodium is a competitive inhibitor of HMG-CoA reductase, the rate limiting enzyme that converts 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) to mevalonate, a precursor of sterols, including cholesterol. The inhibition of cholesterol biosynthesis reduces the cholesterol in hepatic cells, which stimulates the synthesis of LDL receptors and thereby increases the uptake of LDL particles. The end result of these biochemical processes is a reduction of the plasma cholesterol concentration.

Indications

LDL-C

Apo B

and TG

and to increase HDL-C in adult patients with primary hypercholesterolemia and mixed dyslipidemia ( 1.1 ) Reduce elevated TC

LDL-C

and Apo B levels in boys and post-menarchal girls

Contraindications

• 4 CONTRAINDICATIONS Hypersensitivity to any component of this medication ( 4 ) Active liver disease or unexplained
• persistent elevations in serum transaminases ( 4
• 5.3 ) Women who are pregnant or may become pregnant ( 4
• 8.1 ) Nursing mothers ( 4
• women who require treatment with fluvastatin capsules should be advised not to breastfeed their infants [see Use in Specific Populations ( 8.3 )] .

FDA Warnings

5 WARNINGS AND PRECAUTIONS Skeletal muscle effects (e
, myopathy and rhabdomyolysis): Risks increase with advanced age (≥ 65), uncontrolled hypothyroidism, renal impairment, and combination use with cyclosporine,or gemfibrozil
The risk of myopathy and/or rhabdomyolysis with statins is increased with concurrent therapy with cyclosporine, erythromycin, fibrates or niacin
There have been rare postmarketing reports of fatal and non-fatal hepatic failure in patients taking statins, including fluvastatin

Known Side Effects

15 documented side effects by frequency

Muscle Pain

>10%

Dizziness

1-10%

Nausea

1-10%

Diarrhea

1-10%

Shortness of Breath

1-10%

Fatigue

1-10%

Weakness

1-10%

Headache

1-10%

Falls

1-10%

Joint Pain

1-10%

Vomiting

1-10%

Fever

1-10%

Itching

1-10%

General Unwellness

1-10%

Abdominal Pain

0.1-1%

Community Discussions

3 Reddit threads analysed for FLUVASTATIN

Overall Sentiment

Slightly negative

Comparison Threads

Avg Post Score

5 upvotes

Patient Experiences (r/pharmacy, r/AskDocs & more)

How can drugs with very short half lives be administered once daily?

Hey P2 here. Going through the dyslipidemia module I noticed that all statins (except fluvastaton IR) are dosed once daily. How can that be adequate for statins with a super short half life like simvastatin (t1/2 2h)? Wouldnt the drug be almost completely out of your system after 10 hours or so? And

r/pharmacy9195y ago

Question for those that get acute pancreatitis from super high triglycerides

In the past 2 1/2 years I’ve been hospitalized in the ICU twice. First time I was treated with insulin to bring down the triglycerides. The second time insulin stopped working and I had to do two rounds of plasmapheresis. I’ve been taking the highest doses or Fenofibrate, Fluvastatin and now Vasce

r/pancreatitis4218mo ago

Simvastatin can lower histamine, other statins can stabilise mast cells!?

\*\*\*DISCLAIMER\*\*\* I AM NOT A DOCTOR. THIS IS NOT ADVICE. THIS INFORMATION IS FOR DISCUSSION ONLY AND SHOULD NOT BE USED TO FORM ANY KIND OF DIAGNOSIS OR TREATMENT PLAN. Hi all, Whilst doing my homework on Simvastatin, a cholesterol lowering statin medication I am about to start taking, I did

r/HistamineIntolerance245y ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Compare With

4 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral