METOLAZONE

Thiazide Diuretic

Brand names: Metolazone

Oral

Mechanism of Action

Thiazide Diuretic agent

Indications

INDICATIONS AND USAGE Metolazone is indicated for the treatment of salt and water retention including: • edema accompanying congestive heart failure

• edema accompanying renal diseases

including the nephrotic syndrome and states of diminished renal function. Metolazone is also indicated for the treatment of hypertension

alone or in combination with other antihypertensive drugs of a different class. Mykrox ® tablets

a more rapidly available form of metolazone

but which is associated with edema

Contraindications

• CONTRAINDICATIONS Anuria
• hepatic coma or precoma
• known allergy or hypersensitivity to metolazone.

FDA Warnings

WARNINGS Rapid Onset Hyponatremia and/or Hypokalemia Rarely, the rapid onset of severe hyponatremia and/or hypokalemia has been reported following initial doses of thiazide and non-thiazide diuretics
Hypokalemia is a particular hazard in patients who are digitalized or who have or have had a ventricular arrhythmia; dangerous or fatal arrhythmias may be precipitated
Concomitant Therapy Lithium In general, diuretics should not be given concomitantly with lithium because they reduce its renal clearance and add a high risk of lithium toxicity

Known Side Effects

10 documented side effects by frequency

Shortness of Breath

>10%

Nausea

1-10%

Fatigue

1-10%

Diarrhea

1-10%

Dizziness

1-10%

Low Blood Pressure

1-10%

Weakness

1-10%

Headache

1-10%

Peripheral Edema

1-10%

Falls

0.1-1%

Community Discussions

3 Reddit threads analysed for METOLAZONE

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

9 upvotes

Patient Experiences (r/pharmacy, r/AskDocs & more)

Metolazone and furosemide

What is the reasoning behind giving metolazone 30 minutes before furosemide? Is it due to their respective onsets of action?

r/pharmacy14310y ago

K of 5.4 - what would you do?

Patient on KCl 20mEq QD. Also on metolazone 5mg and bumex 1mg. Has history of hypokalemia in last 2 weeks but K came back today at 5.4. Envarsus daily is being increased from 6 to 7mg. I said to DC KCL supplement, instruct patient to decrease dietary K and recheck labs Thurs. Patient is outpatient.

r/pharmacy1193y ago

Chewing metolazone

Has anyone encountered a patient being told to chew metolazone? Is there a reasoning behind it? I can’t find anything that supports it.

r/pharmacy101y ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Compare With

14 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral