What are the most common side effects of OLANZAPINE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for OLANZAPINE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is OLANZAPINE the same as Olanzapine?

Olanzapine is a brand name for OLANZAPINE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

OLANZAPINE

Q: What is OLANZAPINE used for?

OLANZAPINE (brand name Olanzapine) is a Atypical Antipsychotic indicated for refer to the product label for Symbyax. Treatment of treatment resistant depression. ( 1.6 ) Efficacy was established with Symbyax (olanzapine and fluoxetine in combination) in adults, efficacy was established in one 6-week trial [see Clinical Studies ( 14.1 )] . When deciding among the alternative treatments available for adolescents, efficacy was established in one 3-week trial [see Clinical Studies ( 14.2 )] . When deciding among the alternative treatments available for adolescents.

Q: How does OLANZAPINE work?

OLANZAPINE works through the following mechanism: 12.1 Mechanism of Action The mechanism of action of olanzapine, in the listed indications is unclear. However, the efficacy of olanzapine in schizophrenia could be mediated through a combination of dopamine and serotonin type 2 (5HT2) antagonism..

Atypical Antipsychotic

Brand names: Olanzapine, Zyprexa, LYBALVI

Oral

Mechanism of Action

12.1 Mechanism of Action The mechanism of action of olanzapine, in the listed indications is unclear. However, the efficacy of olanzapine in schizophrenia could be mediated through a combination of dopamine and serotonin type 2 (5HT2) antagonism.

Indications

refer to the product label for Symbyax. Treatment of treatment resistant depression. ( 1.6 ) Efficacy was established with Symbyax (olanzapine and fluoxetine in combination) in adults

efficacy was established in one 6-week trial [see Clinical Studies ( 14.1 )] . When deciding among the alternative treatments available for adolescents

efficacy was established in one 3-week trial [see Clinical Studies ( 14.2 )] . When deciding among the alternative treatments available for adolescents

however

diagnosis can be challenging. For pediatric schizophrenia

symptom profiles can be variable

Contraindications

• 4 CONTRAINDICATIONS None with olanzapine monotherapy. When using olanzapine and fluoxetine in combination
• also refer to the Contraindications section of the package insert for Symbyax. For specific information about the contraindications of lithium or valproate
• refer to the Contraindications section of the package inserts for these other products. None with olanzapine monotherapy.( 4 ) When using olanzapine and fluoxetine in combination
• also refer to the Contraindications section of the package insert for Symbyax ® . ( 4 ) When using olanzapine in combination with lithium or valproate
• refer to the Contraindications section of the package inserts for those products. ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS When using olanzapine and fluoxetine in combination, also refer to the Warnings and Precautions section of the package insert for Symbyax
Elderly Patients with Dementia-Related Psychosis: Increased risk of death and increased incidence of cerebrovascular adverse events (e
1 ) Suicide: The possibility of a suicide attempt is inherent in schizophrenia and in bipolar I disorder, and close supervision of high-risk patients should accompany drug therapy; when using in combination with fluoxetine, also refer to the Boxed Warning and Warnings and Precautions sections of the package insert for Symbyax
5 ) Hyperglycemia and Diabetes Mellitus: In some cases extreme and associated with ketoacidosis or hyperosmolar coma or death, has been reported in patients taking olanzapine

Known Side Effects

8 documented side effects by frequency

Drug Not Working

>10%

Weight Gain

>10%

Drowsiness

1-10%

Nausea

1-10%

Fatigue

1-10%

Anxiety

1-10%

Vomiting

1-10%

Condition Worsened

0.1-1%

Community Discussions

9 Reddit threads analysed for OLANZAPINE

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

112 upvotes

Most discussed side effects in community

Rash (1)

Insomnia (1)

Itching (1)

Drowsiness (1)

Tremor (1)

Anxiety (1)

Patient Experiences (r/pharmacy, r/AskDocs & more)

What's the worst side effect you've gotten from your meds? I'll start...

Risperidone made me lactate... yep Latuda made me throw up every single time I took it Olanzapine made me feel like I was drunk Seroquel made me gain 40kg and Lamotrigine gave me the rash

r/bipolar2764294y ago

Rash

After almost 10 years I finally can read again

I couldnt read for almost 10years so maybe even longer. I didn't track the time. I was always a big reader. I finished 700page russian literature in a week. But for some reason I wasn't able to do this anymore. I could barely focus on a few Paragraphs, so I stopped reading. I tried it several times

r/bipolar222512y ago

Good news guys i got accepted in medical school.

8 years stable now on olanzapine, but i sleep 10 hrs each day which is alot for someone who wants to study alot, i switched to abilify 20 days now, everything is good but i have insomnia from olanzapine withdrawal, how much time will it take for me to sleep normal again?

r/schizophrenia131451y ago

Insomnia

Itching

In the psych ward

So they admitted me to the psych ward a few days ago after my last post. The first night i couldn't keep my blankie and blew up and punched the shit out of my face so i have two big black eyes and my whole right hand is greeny purple. When the psychiatrist saw me the next morning (sobbing and hyster

r/bipolar82167y ago

Drowsiness

Tremor

Diagnosed Today with Bipolar and Borderline Personality Disorder

i have a ton of questions that i would love to unload on people. but just for now i would like to know one thing... i have meds now "olanzapine" through my psychiatrist. what is something you wish you knew before taking your meds that you know now? also im not worried about the meds, i'm just being

r/bipolar72744y ago

Just got diagnosed at 30

I’m 30. I have struggled with this my whole life , unbeknownst to me. I went to multiple doctors and counselors, especially after I had my kids and was crying to them telling them there is something wrong with me please figure it out. They did labs and all kinds of testing. They told me it was in m

r/bipolar64323y ago

On meds forever?

Anyone else have bipolar and told you have to take meds for life? I am worried about the long term effects of the meds but I am also worried about how I would do if I went off them. I am currently doing great. My meds are zyprexa/olanzapine and lithium.

r/bipolar641102y ago

After about 7yrs, I've finally quit olanzapine

And holy shit do I stink now. Not my whole body, mostly the armpits and it's like the really sharp and nasty sweat smell that usually comes from men who don't know what a deodorant is. This is what I wake up to every morning, F31 (Oh hey, that's the code for BP, never noticed this). Tbf I sweat exc

r/bipolar52212y ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → OLANZAPINE openFDA label JSON → OLANZAPINE FAERS adverse-event reports → OLANZAPINE ClinicalTrials.gov → completed Phase 2+ trials of OLANZAPINE

Compare With

31 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral