Brand names: Sildenafil Citrate, Viagra, Revatio
12.1 Mechanism of Action The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation. Binding Characteristics Studies in vitro have shown that sildenafil is selec
Contraindications
11 documented side effects by frequency
12 Reddit threads analysed for SILDENAFIL
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Mixed
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119 upvotes
Most discussed side effects in community
https://imgur.com/a/jyU3YII My baby has been in the hospital for a week and they just keep finding more stuff wrong with him. Pretty sure I just had a nervous breakdown because there is no solution or plan and I just want to figure out what’s wrong. TL;DR: heart murmur, pulmonary hypertension, PDA,
I’m reaching out for advice and support regarding my boyfriend, who is currently in the hospital on a ventilator. He’s 37 years old, 5'8", and weighs 180 pounds. His health has deteriorated rapidly over the past few months, and I’m desperate to find answers. In July, he took some herbal Chinese medi
Inspired by the very interesting and informative pharmacy in Denmark thread, I thought I would tell you about pharmacy in my country. * Pharmacy is a 4 year undergraduate degree and to become a registered pharmacist, you must also complete a year of supervised practice (called internship but it is p
I have a patient who has been refilling his sildenafil earlier and earlier each month. It's for 100mg once daily for ED. So far he's had 5 fills since the beginning of the year. Each Rx has been for 30 tablets for a 30 day supply. To be more specific the dates are: * 01/05/24 * 01/22/24 (17 days)\*
I'm desperate for help, this is not an ER-level emergency but I'm scared and need direction. Husband is 38, caucasian, 5'10" and about 200-215 lbs. Only past medical issues were the occasional migraines as a teenager (Imitrex) and mild ED (Sildenafil). We are in Ontario, Canada. He's in moderately g
Why do seasoned doctors still write so many rx without frequency? I’m working at a store that is getting killed by rite aid transfer in and I don’t have time for them! Omeprazole 20 mg “take 1 capsule as directed as needed” Oxycodone 30 mg “take 1 tablet as needed for pain” Sildenafil 20 “take 1-5
I have a ton of patients trying to be on both sildenafil and tadalafil, and at their highest strengths. Correct me if I’m wrong but they both work the same exact way with minuscule differences (without food/ no regards to food and duration of action obviously), but what on the world is going on? No
Please help….is there any justification for a patient to be taking both these #30 and refilling both of them about every 15-20 days? This guy got mad when I wouldn’t fill both for him and said how he was a male stripper that needed these to survive
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6 available comparisons
Dosage Forms
Tablet
Route
Oral