TRAZODONE HYDROCHLORIDE

Atypical Antidepressant

Brand names: Trazodone Hydrochloride

Oral

Mechanism of Action

12.1 Mechanism of Action The mechanism of trazodone's antidepressant action is not fully understood, but is thought to be related to its enhancement of serotonergic activity in the CNS. Trazodone is both a selective serotonin reuptake inhibitor (SSRI) and a 5HT2 receptor antagonist and the net result of this action on serotonergic transmission and its role in trazodone's antidepressant effect is unknown.

Indications

See full prescribing information

Contraindications

• 4 CONTRAINDICATIONS None ( 4 ). Concomitant use of monoamine oxidase inhibitors (MAOIs)
• or use within 14 days of stopping MAOIs ( 4 ). Trazodone hydrochloride tablets are contraindicated in: Patients taking
• or within 14 days of stopping
• monoamine oxidase inhibitors (MAOIs)
• including MAOIs such as linezolid or intravenous methylene blue

FDA Warnings

5 WARNINGS AND PRECAUTIONS Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents (e
Avoid use with drugs that also increase the QT interval and in patients with risk factors for prolonged QT interval ( 5
3 ) Orthostatic Hypotension and Syncope: Warn patients of risk and symptoms of hypotension ( 5
Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5

Known Side Effects

13 documented side effects by frequency

Drug Not Working

>10%

Fatigue

1-10%

Nausea

1-10%

Headache

1-10%

Diarrhea

1-10%

Vomiting

1-10%

Insomnia

1-10%

Depression

1-10%

Shortness of Breath

1-10%

Dizziness

1-10%

Falls

1-10%

Weakness

0.1-1%

Anxiety

0.1-1%

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Compare With

7 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral