TRAZODONE HCL vs TRAZODONE HYDROCHLORIDE

Compare TRAZODONE HCL (Trazodone HCL) and TRAZODONE HYDROCHLORIDE (Trazodone Hydrochloride) — clinical data, side effects, and patient experiences.

TRAZODONE HCL

Trazodone HCL · Atypical Antidepressant

How it works

Other agent

Approved for

Trazodone hydrochloride tablets

USP are indicated for the treatment of major depressive disorder (MDD) in adults.

OralTablet

TRAZODONE HYDROCHLORIDE

Trazodone Hydrochloride · Atypical Antidepressant

How it works

12.1 Mechanism of Action The mechanism of trazodone's antidepressant action is not fully understood, but is thought to be related to its enhancement of serotonergic activity in the...

Approved for

See full prescribing information

OralTablet

Quick Comparison

TRAZODONE HCLTRAZODONE HYDROCHLORIDE

Drug Class

Atypical Antidepressant

Route

Oral

Half-Life

—

FDA Approved

—

Side Effect Frequency Comparison

Estimated frequency (%) based on clinical trial data

Side Effects

TRAZODONE HCL

Drug Not Working

>10%

Fatigue

1-10%

Nausea

1-10%

Headache

1-10%

Diarrhea

1-10%

Vomiting

1-10%

Insomnia

1-10%

Depression

1-10%

TRAZODONE HYDROCHLORIDE

Drug Not Working

>10%

Fatigue

1-10%

Nausea

1-10%

Headache

1-10%

Diarrhea

1-10%

Vomiting

1-10%

Insomnia

1-10%

Depression

1-10%

FDA Warnings

TRAZODONE HCL

The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St
The concomitant use of trazodone with MAOIs is contraindicated
If concomitant use of trazodone with other serotonergic drugs is clinically warranted, inform patients of the increased risk for serotonin syndrome and monitor for symptoms
Trazodone should also be avoided in patients with a history of cardiac arrhythmias, as well as other circumstances that may increase the risk of the occurrence of torsade de pointes and/or sudden death, including symptomatic bradycardia, hypokalemia or hypomagnesemia, and the presence of congenital prolongation of the QT interval

TRAZODONE HYDROCHLORIDE

5 WARNINGS AND PRECAUTIONS Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents (e
Avoid use with drugs that also increase the QT interval and in patients with risk factors for prolonged QT interval ( 5
3 ) Orthostatic Hypotension and Syncope: Warn patients of risk and symptoms of hypotension ( 5
Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5

Clinical Trial Data

No head-to-head clinical studies found for TRAZODONE HCL vs TRAZODONE HYDROCHLORIDE.

TRAZODONE HCL vs TRAZODONE HYDROCHLORIDE: What You Should Know

Key Differences

Both TRAZODONE HCL and TRAZODONE HYDROCHLORIDE belong to the Atypical Antidepressant class. While they share a similar mechanism of action, differences in pharmacokinetics, dosing, and side effect profiles may make one more suitable than the other for individual patients.

Safety Considerations

TRAZODONE HCL carries 4 FDA warnings. TRAZODONE HYDROCHLORIDE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..

This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.

Related Comparisons

TRAZODONE HCL vs VILAZODONE HYDROCHLORIDE→TRAZODONE HYDROCHLORIDE vs VILAZODONE HYDROCHLORIDE→NEFAZODONE HYDROCHLORIDE vs TRAZODONE HCL→NEFAZODONE HYDROCHLORIDE vs TRAZODONE HYDROCHLORIDE→MIRTAZAPINE vs TRAZODONE HCL→MIRTAZAPINE vs TRAZODONE HYDROCHLORIDE→

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TRAZODONE HCL vs TRAZODONE HYDROCHLORIDE

Compare TRAZODONE HCL (Trazodone HCL) and TRAZODONE HYDROCHLORIDE (Trazodone Hydrochloride) — clinical data, side effects, and patient experiences.

TRAZODONE HCL

Trazodone HCL · Atypical Antidepressant

How it works

Other agent

Approved for

Trazodone hydrochloride tablets

USP are indicated for the treatment of major depressive disorder (MDD) in adults.

OralTablet

TRAZODONE HYDROCHLORIDE

Trazodone Hydrochloride · Atypical Antidepressant

How it works

12.1 Mechanism of Action The mechanism of trazodone's antidepressant action is not fully understood, but is thought to be related to its enhancement of serotonergic activity in the...

Approved for

See full prescribing information

OralTablet

Quick Comparison

TRAZODONE HCLTRAZODONE HYDROCHLORIDE

Drug Class

Atypical Antidepressant

Route

Oral

Half-Life

—

FDA Approved

—

Side Effect Frequency Comparison

Estimated frequency (%) based on clinical trial data

Side Effects

TRAZODONE HCL

Drug Not Working

>10%

Fatigue

1-10%

Nausea

1-10%

Headache

1-10%

Diarrhea

1-10%

Vomiting

1-10%

Insomnia

1-10%

Depression

1-10%

TRAZODONE HYDROCHLORIDE

Drug Not Working

>10%

Fatigue

1-10%

Nausea

1-10%

Headache

1-10%

Diarrhea

1-10%

Vomiting

1-10%

Insomnia

1-10%

Depression

1-10%

FDA Warnings

TRAZODONE HCL

The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St
The concomitant use of trazodone with MAOIs is contraindicated
If concomitant use of trazodone with other serotonergic drugs is clinically warranted, inform patients of the increased risk for serotonin syndrome and monitor for symptoms
Trazodone should also be avoided in patients with a history of cardiac arrhythmias, as well as other circumstances that may increase the risk of the occurrence of torsade de pointes and/or sudden death, including symptomatic bradycardia, hypokalemia or hypomagnesemia, and the presence of congenital prolongation of the QT interval

TRAZODONE HYDROCHLORIDE

5 WARNINGS AND PRECAUTIONS Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents (e
Avoid use with drugs that also increase the QT interval and in patients with risk factors for prolonged QT interval ( 5
3 ) Orthostatic Hypotension and Syncope: Warn patients of risk and symptoms of hypotension ( 5
Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5

Clinical Trial Data

No head-to-head clinical studies found for TRAZODONE HCL vs TRAZODONE HYDROCHLORIDE.

TRAZODONE HCL vs TRAZODONE HYDROCHLORIDE: What You Should Know

Key Differences

Safety Considerations

This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.