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Brand names: Valsartan, Diovan
12.1 Mechanism of Action Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Valsartan tablets blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis. There is also an AT2 receptor found in many tissues, but AT2 is not known to be associated with cardiovascular homeostasis. Valsartan has much greater affinity (about 20,000-fold) for the AT1 receptor than for the AT2 receptor. The increased plasma levels of angiotensin II following AT1 receptor bl
13 documented side effects by frequency
15 Reddit threads analysed for VALSARTAN
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9 upvotes
Most discussed side effects in community
I think this past year has been the worst year of my life. In January I had a hypertensive crisis and checked into the ER with a BP of 213/110+ I’m pretty sure I was walking around like this for months not knowing it until my body told me something was wrong. Got put on Amlodipine as a first line me
Saw my Dr. on Jan 5 and reviewed my BP trends since October. He agreed to let me stop the drug. I’ll continue to track one because I dropped a load on a smart BP monitor, also to see if I do need to restart down the line. This is really exciting for me, I got more active over the course of 2025 an
I’ve been on a beta blocker since I was 25 (I’m 42 now) and my doc added valsartan about 3 years ago during the pandemic (during which time I was under a lot of stress and drank more alcohol). During the worst of that time I probably drank 10-15 drinks a week. Never been overweight, though, and regu
Started going to a new cardiologist for HBP three years ago. Initially he put me on Valsartan, but switched me to Lorsartan (you know, because of the whole rocket fuel thing). Then put me on a mild dose of HCTZ. Then about three years ago, he put me on carvidelol (the beta blocker). Long story short
Hi all, Writing for support. About 2 months ago I went to an unrelated GP appointment and a routine BP reading was taken. My BP was 180/120, several more were taken and it was still the same. I’m 27 female, 60kg, exercise regularly (mostly weights not cardio). I was quickly seen by a cardiologist an
A while ago I was put on Amlodipin and ended up in the ER after all bowel movements stopped.. according to my Dr, that was a very rare side effect he had personally never heard of. A month ago I was at the Dr office again after a few months without meds and my BP was 160/100. I was put on Valsartan
A few years ago, I went for a checkup during a time of high anxiety, I was even having panic attacks randomly and having insomnia. Obviously the readings were high 145/95 and was prescribed with valsartan. After that I got treatment for anxiety, and feel a lot better but now I am affraid to leave
Hi everybody I have tried all these three Losartan, Valsartan, Amlodipine. They all make me feel dizzy, stressed out, worried and depressed. Have someone had the same issues? Don’t know really what to do. I felt my health has really decreased since started on BP medicines. Thanks to all.God bless e
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22 available comparisons
Dosage Forms
Tablet
Route
Oral