Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare AMLODIPINE (amlodipine) and Lisinopril (Zestril) — clinical data, side effects, and patient experiences.
amlodipine, Norvasc, Exforge HCT · ARB
How it works
12.1 Mechanism of Action The active ingredients of amlodipine, valsartan and hydrochlorothiazide tablets target 3 separate mechanisms involved in blood pressure regulation. Specifi...
Approved for
Zestril, Prinivil · ACE Inhibitor
How it works
Inhibits angiotensin-converting enzyme (ACE), preventing conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, leading to decreased blood pressure and reduced al...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 30 Reddit discussions
AMLODIPINE
27%
positive
15 threads
Lisinopril
47%
positive
15 threads
% of discussions mentioning each side effect
15 Reddit threads analysed for AMLODIPINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
71 upvotes
Most discussed side effects in community
From 200+ BP to Controlled Levels of 100-120: My Journey as a 22-Year-Old with Severe Hypertension I’m 22 and recently discovered I had severe hypertension with blood pressure readings in the 200s. It’s possible I lived with those dangerous numbers for years without realizing it. For as long as I c
Back in April, I stopped taking my meds after 21 years (360mg of Valsartan + 5mg Amlodipine) because I was tired of taking pills every day, and I wanted to break free from our backwards "sickcare" system. I've long suspected that the bp meds cause us to become dependent on them, and since they do n
35 male with high BP my entire life Been on it for 1 year and 5 months. Started at 5 mg for like 3 or 6 months then went to 10 mg. Seems I have a barrage of symptoms I’ve never had before in my life for the last 6 months. Extreme daytime sleepiness***** The chills like 15 times a day ***** Swollen
I've been on Amlodipine and Carvedilol since June of 2025. I tried to stop Amlodipine without doctor's approval because it makes my anxiety worse. I tried to move up my next doctor's appointment to see if I can switch to something else like an Ace Inhibitor, but the closest they could slot me in was
About a month ago I was hospitalized. I was driving with my daughter and suddenly felt shortness of breath, dizziness and the feeling like I was going to pass out. I pulled over caught my breath and out of pure adrenaline was able to make it home and call an ambulance when they came my BP was 198/12
I was hungover, ate prosciutto, hands were shaking like crazy. I thought I'd measure it just for the fun of it. It wasn't fun when the numbers never in 10 measurement went lower than 210/120, going to the ER made things worse. It was all in my head. But we fixed it. Hell started. 2 months passed and
Just wanted to brag on myself a bit here. Since February I've been taking GLP-1 and I'm down 45lbs (247-202). My GW is 170 so I still have a ways to go but recently I've been having weird dizzy spells when bending down and standing back up. There are a lot of potential causes of course, but my BP ha
Been on medication for high blood pressure for about 4 years now, and finally found a cocktail of meds that seems to be working for me: Bisoprolol 2.5mg tablets Indapamide 1.5mg modified-release tablets Amlodipine 10mg tablets Ramipril 10mg tablets Spironolactone 25mg tablets Systolic still high but
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 Reddit threads analysed for Lisinopril
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
57 upvotes
Most discussed side effects in community
3 months after an initial 177/112 reading in the hospital and 168/109 reading at the doctors the next day. I have finally begun to hit below 120/80. Currently taking lisinopril 20mg and am hoping to be off it by September which is my next checkup. I swapped diets, went from never leaving the house t
Pretty much exactly two months after my hypertensive crisis that saw me in hospital. I'm very firmly in the normal range. Unfortunately, I've got a bit of kidney damage and my eyes had hemorrhages from undiagnosed diabetes along with this. Nothing that can't be managed. The 40mg lisinopril, 10 mg
I wanted to share my experience in case it helps someone who might be in the same confusing situation I was in. I’m a **46 year old male,** fairly active, healthy weight, and generally careful with my lifestyle. About a year and a half ago, I started paying closer attention to my blood pressure, whi
First, thanks to this sub for all the helpful information I've been able to take from all your posts. Grateful for this resource and practical experience from you all. This is my first post here, but wanted to share my story in hopes it might calm someone down who is starting their process. In early
Morning BP much better, two weeks in starting Valsartan, used to take lisinoprill, now on arb, 72 years old.
When doc wanted to double my meds in May (Lisinopril 10mg to 20mg), I lost it. I thought I was on track to drop meds but didn’t have the nerve to check my own pressure at home due to anxiety about the numbers. Lost 10 lbs, eating like a vegetarian, quit booze, started walking and meditating. Grant
A month an a half ago it was 150/92. Lisinopril 10mg worked for me
Just wanted to share my story of getting my BP under control as motivation for all of us who struggle with it. I am 46 yo, fit and athletic individual (155lbs, distance runner, scuba diver) who had a reasonably good diet and mild alcohol use. During a regular health checkup, my BP was very high and
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
AMLODIPINE is a ARB, while Lisinopril belongs to the ACE Inhibitor class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
AMLODIPINE carries 4 FDA warnings. Lisinopril carries 2 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.