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Brand names: amlodipine, Norvasc, Exforge HCT
12.1 Mechanism of Action The active ingredients of amlodipine, valsartan and hydrochlorothiazide tablets target 3 separate mechanisms involved in blood pressure regulation. Specifically, amlodipine blocks the contractile effects of calcium on cardiac and vascular smooth muscle cells; valsartan blocks the vasoconstriction and sodium retaining effects of angiotensin II on cardiac, vascular smooth muscle, adrenal and renal cells; and hydrochlorothiazide directly promotes the excretion of sodium and chloride in the kidney leading to reductions in intravascular volume. A more detailed description of the mechanism of action of each individual component follows. Amlodipine Amlodipine is a dihydropyridine calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Experimental data suggest that amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular
Contraindications
12 documented side effects by frequency
15 Reddit threads analysed for AMLODIPINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
71 upvotes
Most discussed side effects in community
From 200+ BP to Controlled Levels of 100-120: My Journey as a 22-Year-Old with Severe Hypertension I’m 22 and recently discovered I had severe hypertension with blood pressure readings in the 200s. It’s possible I lived with those dangerous numbers for years without realizing it. For as long as I c
Back in April, I stopped taking my meds after 21 years (360mg of Valsartan + 5mg Amlodipine) because I was tired of taking pills every day, and I wanted to break free from our backwards "sickcare" system. I've long suspected that the bp meds cause us to become dependent on them, and since they do n
35 male with high BP my entire life Been on it for 1 year and 5 months. Started at 5 mg for like 3 or 6 months then went to 10 mg. Seems I have a barrage of symptoms I’ve never had before in my life for the last 6 months. Extreme daytime sleepiness***** The chills like 15 times a day ***** Swollen
I've been on Amlodipine and Carvedilol since June of 2025. I tried to stop Amlodipine without doctor's approval because it makes my anxiety worse. I tried to move up my next doctor's appointment to see if I can switch to something else like an Ace Inhibitor, but the closest they could slot me in was
About a month ago I was hospitalized. I was driving with my daughter and suddenly felt shortness of breath, dizziness and the feeling like I was going to pass out. I pulled over caught my breath and out of pure adrenaline was able to make it home and call an ambulance when they came my BP was 198/12
I was hungover, ate prosciutto, hands were shaking like crazy. I thought I'd measure it just for the fun of it. It wasn't fun when the numbers never in 10 measurement went lower than 210/120, going to the ER made things worse. It was all in my head. But we fixed it. Hell started. 2 months passed and
Just wanted to brag on myself a bit here. Since February I've been taking GLP-1 and I'm down 45lbs (247-202). My GW is 170 so I still have a ways to go but recently I've been having weird dizzy spells when bending down and standing back up. There are a lot of potential causes of course, but my BP ha
Been on medication for high blood pressure for about 4 years now, and finally found a cocktail of meds that seems to be working for me: Bisoprolol 2.5mg tablets Indapamide 1.5mg modified-release tablets Amlodipine 10mg tablets Ramipril 10mg tablets Spironolactone 25mg tablets Systolic still high but
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20 available comparisons
Dosage Forms
Tablet
Route
Oral