Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare BUPROPION (bupropion) and DULOXETINE (DULOXETINE HYDROCHLORIDE) — clinical data, side effects, and patient experiences.
bupropion, Wellbutrin, Zyban · Atypical Antidepressant (NDRI)
How it works
12.1 Mechanism of Action The mechanism of action of bupropion is unknown, as is the case with other antidepressants. However, it is presumed that this action is mediated by noradre...
Approved for
DULOXETINE HYDROCHLORIDE, Cymbalta · SNRI
How it works
12.1 Mechanism of Action Although the exact mechanisms of the antidepressant, central pain inhibitory and anxiolytic actions of duloxetine in humans are unknown, these actions are ...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 28 Reddit discussions
BUPROPION
54%
positive
13 threads
DULOXETINE
27%
positive
15 threads
% of discussions mentioning each side effect
13 Reddit threads analysed for BUPROPION
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
69 upvotes
Most discussed side effects in community
As I get older, I’m starting to become more aware of the telltale signs that my depression symptoms are getting worse. I’ve noticed that one very specific symptom is that I feel nostalgic about so many things. In a melancholy way, not a fun way. I think it’s my brain’s way of trying to comfort me by
I obviously am not cured but it’s easily my favorite one I’ve been on. I want to know if y’all have ever started a med and were just blown away!! For me, it’s Bupropion (Wellbutrin XL). It helped reduce my depression smoking and my lack of motivation. I’ve genuinely never been happier. ETA: It’s bee
I have been a reader of this sub-reddit for some time now, but it is time for me to post. I am a first generation Asian-American and I have severe depression. I am taking bupropion sr1 at 50mg. The meds work for the most part to the extent that I can function, but at times I feel a huge surge of
So as the title suggests, ive recently come out of a huge stent of depression, about 10 years worth. Because of how long ive been depressed, most of my entire personality was taken over by it. I became withddrawn, self defeating, gave up my activities and hobbies years ago because they were no long
I have been so exhausted lately that I am on the verge of dizziness some days. I get about eight hours of sleep, so I should be well rested enough, but I wake up barely able to get out of bed. It's also really cold right now, which is sapping a lot of what little energy I have left. I am trying not
After four years on a low dose of bupropion XL (100 mg) , I decided to stop taking it. My pharmacist told me to taper off slowly, so for the first 2.5 weeks I took it every 2nd day, and for the next 2.5 weeks I took it every 3rd day. The tapering process went smoothly, so I figured it was safe to st
I’ve been depressed and anxious since I was 10 (turning 22 this year..) and it almost feels like every year, I just lose a piece of myself. Every year, I lose more energy and more hope. I struggle with so much self doubt and self hatred. I wouldn’t kill myself but I often think of how great it would
I'm only 4 foot 10, and gained about 15 pounds in 4 months on mirtazapine. That is something like the equivalent of 6 or 8 dress sizes. I need to stay on the drug because of the severity of my depression and sleep dysfunction, with long covid. Over the course of 2 months I've lost 9 of those pounds,
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 Reddit threads analysed for DULOXETINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
43 upvotes
Most discussed side effects in community
I am a 28 year old man and I've just realized that nothing interests me. I believe that it might be connected to depression as I am on medication for depression and anxiety (duloxetine) I am not really sad or anything. I am just very neutral. Things that used to interest, excite me and make me happ
I have been recovering from over a decade of major depressive disorder and recently diagnosed bipolar II. I’m seeing light at the end of the tunnel with Lamotrigine and lifestyle changes, and after several mental health evaluations, my psychiatrist gave me the best news ever; I can stop taking antid
Hi, just wondering if this is a common experience: So i've been taking agomelatine 50mg for about 5 months and duloxetine 60mg for 3 months now for severe depression and anxiety. The antidepressants have been working just as intended in the sense that most of the mental agony has gone, but there's
I ( M23) have been taking duloxetine 60 mg for 2 years now. While it has helped tremendously with my anxiety/depression/DPDR, it did cause sexual side effects for me. (I also take lamotrigine, but that is unlikely to cause effects like this) For me, these sides were very annoying; my main problem wa
Entry time 8:55am Before I went to sleep last night, I had nurses come 2 times, around 9:30pm and then at 10:40pm asking if I wanted to take some anxiety medication to help me sleep better. I refused both times as it wasn't initially prescribed, and in general I don't have a problem sleeping. My al
UHC is canceling coverage of my medication: Lamotrigine, Atomoxetine, and Duloxetine. Starts in January. Im barely getting by as it is. I need to find new insurance asap (Im in the USA). Its no wonder they were targeted. I just learned that they deny the most coverage of any US health insurer. Wtf a
Since the late of 2019 year, till now I've tried: 1- Escitalopram "Lexapro" (tried Atomoxetine "Strattera" with it, then stopped it due to its bad effects) (tried Risperidone "Rispardal" then stopped it, it hasn't only bad effects, but also highly increased prolactin) 2- Fluoxetine "Prozac" 3- Bupro
You know how a lot of sources say working towards a goal and then achieving it gives a sense of reward via dopamine? This week I got a pay rise, achieved a fitness goal I've been working towards for months and even got asked out on a date by someone quite attractive. But I feel absolutely nothing.
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
BUPROPION is a Atypical Antidepressant (NDRI), while DULOXETINE belongs to the SNRI class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
BUPROPION carries 4 FDA warnings. DULOXETINE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.