CRIZOTINIB vs IBRUTINIB

**Verified?** *(This bot cannot verify AMAs just yet)* **Date:** 2013-02-21 **[Link to submission](http://www.reddit.com/r/IAmA/comments/18ymad/)** (*Has self-text*) **[Link to my post](http://www.reddit.com/r/IAmA/comments/18ymad/tabledresser/c8jk1ce)** Questions|Answers :--|:-- [Would you rather m

Hello, My husband has ROS1-positive lung cancer with multiple brain metastases. He was treated with Crizotinib, but unfortunately the brain metastases have progressed. We are considering Lorlatinib as the next treatment option, but we have concerns about availability, cost, side effects, and the app

Hi all, I have posted here before a few times about my dad (64M). He was diagnosed with NSCLC adenocarcinoma stage 4 mets to hip on December 2024. He went through 6 rounds of chemo, tumors responded (shrunk a little but still active) and was disease was considered stable. Then he was put on maintena

Hey everyone, I hoped to pose a question. The UK NHS does not use MET amplification as a biomarker for mutation testing. My father, who has Stage 4 non-small cell lung cancer, was put on the conventional treatment regimen, chemo + immunotherapy (carboplatin-pemetrexed-pembrolizumab), because nothi

Hi, I have a rare stage-IV soft tissue sarcoma with mets to the lungs and lymph nodes. Does anyone on here have any experience with crizotinib (brand name in the USA is Xalkori)? I was taking another, similar MET inhibitor (cabozantinib/Cabometyx), but I'm switching due to progression while on cabom

Hello, My husband has ROS1-positive lung cancer with multiple brain metastases. He was treated with Crizotinib, but unfortunately the brain metastases have progressed. We are considering Lorlatinib as the next treatment option, but we have concerns about availability, cost, side effects, and the app

Hey everyone, get ready for some deep due diligence, this time not for REGAL, but for SLS-009, buyout, and what the future will look like with buyout from a strategic acquirer. Before I start, I would suggest for those haven’t yet, read Part 1 and Part 2 that goes over the deep due diligence and mac

Hey everyone, get ready for some deep due diligence, this time not for REGAL, but for SLS-009, buyout, and what the future will look like with buyout from a strategic acquirer. Before I start, I would suggest for those haven’t yet, read Part 1 and Part 2 that goes over the deep due diligence and mac

Hi everyone. I’m looking for insight from others with CLL experience. My dad has CLL with 96% involvement in his bone marrow per recent biopsy. His platelets are low, and over the past two weeks his anemia has worsened very very quickly. Recent timeline: Hospitalized with hemoglobin \~7.5 and fever

To Those Who Wish to learn, I feel like I may be giving away a secret.... but... here it goes... Earlier today I had a [twitter conversation](https://twitter.com/sentivcapital/status/1663230898702106634) about AI in regards to potential for future impact on stocks. I received a lot of DMs and to be

I’ve been pretty successful in a media career but now, at 43, 3 years post my diagnosis with my cancer under control (no cure... a rare lymphoma/on ibrutinib forever) two kids 7 and 4 at home and the sole breadwinner for the family, I’m so disenchanted. I finally feel great health wise... back to m

I was researching to find out * Examples of cancer drugs in the past that came to market later where treatments already existed, but ended up being commercially successful - * What were the characteristics of these late entrants that led to their success and does Cosibelimab have some of these char

**Is progression a meaningful outcome measure for a patient with indolent lymphoma** **If I don't feel anything (i.e. asymptomatic) and can live for decades with my lymphoma should I even worry about the fact that I have some enlarged lymph nodes or abnormalities of my lab work ???** I had a dis

Apparently a patient had been administering the medication this way... It's on the ISMP do not crush list. I called the manufacturer (Pharmacyclics) and they had no data on administering through any enteral feeding tubes, so they recommended not to give the medication in this manner. I can't find an