Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare DICLOFENAC (Xiclo) and DULOXETINE (DULOXETINE HYDROCHLORIDE) — clinical data, side effects, and patient experiences.
Xiclo, Voltaren · NSAID
How it works
Other agent
Approved for
DULOXETINE HYDROCHLORIDE, Cymbalta · SNRI
How it works
12.1 Mechanism of Action Although the exact mechanisms of the antidepressant, central pain inhibitory and anxiolytic actions of duloxetine in humans are unknown, these actions are ...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 30 Reddit discussions
DICLOFENAC
20%
positive
15 threads
DULOXETINE
27%
positive
15 threads
% of discussions mentioning each side effect
15 Reddit threads analysed for DICLOFENAC
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
55 upvotes
Most discussed side effects in community
Hello reddit and fellow chronic pain people. I posted on here about 2 days ago asking for help because I was in severe pain from open heart surgery I just had on top of my CRPS in my hip and chronic back pain, and they gave me tramadol which didn't help that much and diclofenace gel and told me to m
Background info i'm 19. Have stage 4 congestive heart failure (terminal illness), severe debilitating pain. I have neck pain, chest pain in the middle of my chest thats nerve pain after open heart surgery, pain in my heart area. Pain and Spasms in my back, mostly lower back. Left Hip pain from surge
First I want to preface this by saying everyone's pain is different and pain meds are a totally valid treatment. A couple months ago I finally decided to do a spinal cord stimulator for my low back and down the leg sciatic pain. And especially the severe pain in my hip from this. Four months on I ha
My doctors told me I have mild inflammation in my bladder. I can't take ibuprofen, so I was prescribed Prednisone for a while, then Diclofenac. Neither helped. I do drink around a gallon of water everyday but I will spend hours in the bathroom. Just peeing. It's usually in little spurts but everytim
I gave it about a week with some Diclofenac. 23 years later...
I have arthritis, chronic fatigue, and chronic headaches. Sometimes just walking down the hall is hard as my knees scream at me with every step. It's hard to function when my body is telling me I need fourteen hours of sleep a day. And the headache never. Fully. Stops. And I just had to listen to f
I went to the ER today after my doctor worried that I might have Cauda Equina (negative), and the ER attending suggested that I try Diclofenac to manage my nerve pain as I wait for a diagnosis (it's been a year into testing, next up are nerve conduction tests and EMGs). I told him that I had previou
Desperate for any help, i decided to try this. Supposed to give it a week. I have only used it since yesterday. It is a topical NSAID so I never bothered with it. Needs reapplication every 4 hrs in the US and not labeled for back (just extremities). It really seems to be doing something so for now I
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 Reddit threads analysed for DULOXETINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
43 upvotes
Most discussed side effects in community
I am a 28 year old man and I've just realized that nothing interests me. I believe that it might be connected to depression as I am on medication for depression and anxiety (duloxetine) I am not really sad or anything. I am just very neutral. Things that used to interest, excite me and make me happ
I have been recovering from over a decade of major depressive disorder and recently diagnosed bipolar II. I’m seeing light at the end of the tunnel with Lamotrigine and lifestyle changes, and after several mental health evaluations, my psychiatrist gave me the best news ever; I can stop taking antid
Hi, just wondering if this is a common experience: So i've been taking agomelatine 50mg for about 5 months and duloxetine 60mg for 3 months now for severe depression and anxiety. The antidepressants have been working just as intended in the sense that most of the mental agony has gone, but there's
I ( M23) have been taking duloxetine 60 mg for 2 years now. While it has helped tremendously with my anxiety/depression/DPDR, it did cause sexual side effects for me. (I also take lamotrigine, but that is unlikely to cause effects like this) For me, these sides were very annoying; my main problem wa
Entry time 8:55am Before I went to sleep last night, I had nurses come 2 times, around 9:30pm and then at 10:40pm asking if I wanted to take some anxiety medication to help me sleep better. I refused both times as it wasn't initially prescribed, and in general I don't have a problem sleeping. My al
UHC is canceling coverage of my medication: Lamotrigine, Atomoxetine, and Duloxetine. Starts in January. Im barely getting by as it is. I need to find new insurance asap (Im in the USA). Its no wonder they were targeted. I just learned that they deny the most coverage of any US health insurer. Wtf a
Since the late of 2019 year, till now I've tried: 1- Escitalopram "Lexapro" (tried Atomoxetine "Strattera" with it, then stopped it due to its bad effects) (tried Risperidone "Rispardal" then stopped it, it hasn't only bad effects, but also highly increased prolactin) 2- Fluoxetine "Prozac" 3- Bupro
You know how a lot of sources say working towards a goal and then achieving it gives a sense of reward via dopamine? This week I got a pay rise, achieved a fitness goal I've been working towards for months and even got asked out on a date by someone quite attractive. But I feel absolutely nothing.
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
DICLOFENAC is a NSAID, while DULOXETINE belongs to the SNRI class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles. DICLOFENAC is administered via Transdermal, whereas DULOXETINE uses Oral. Route of administration can affect onset of action and patient adherence.
DICLOFENAC carries 4 FDA warnings. DULOXETINE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.