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Compare Losartan (Cozaar) and SPIRONOLACTONE (Spironolactone) — clinical data, side effects, and patient experiences.
Cozaar · ARB (Angiotensin II Receptor Blocker)
How it works
Selectively blocks the binding of angiotensin II to the AT1 receptor found in many tissues, reducing vasoconstriction, aldosterone secretion, and sympathetic activity.
Approved for
Spironolactone, Aldactone · Aldosterone Antagonist
How it works
12.1 Mechanism of Action Spironolactone and its active metabolites are specific pharmacologic antagonists of aldosterone, acting primarily through competitive binding of receptors ...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 10 Reddit discussions
Losartan
10%
positive
10 threads
SPIRONOLACTONE
0%
positive
0 threads
% of discussions mentioning each side effect
10 Reddit threads analysed for Losartan
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
51 upvotes
Most discussed side effects in community
Today went to see my cardiologist and no longer need to take losartan nor atorvastatin ! Got to a healthy weight and good diet that he said I no longer need the medication. Hopefully I can stay off it from now on. Im 5,8 went from 225lbs down to 185, eating a lot of food with high sodium to no/low
Hi, how is it going. Today I'm officially off blood pressure meds completely. With lifestyle changes, low sodium diet, low sugar, aerobic exercise and weight loss. I had blood pressure in the 170 to 180 systolic in January of 2025 after heart surgery on November 2024. I was 230 pounds and am current
I take 100 mg of Losartan daily, but before meds I was easily in the 140-150/90-100 range. Even after taking medication I was usually in the 130/90+ range. My resting heart rate used to sit at about 110 too. I felt like shit and my bod was so tense. But recently I stopped drinking and smoking and be
My blood pressure (seemingly) started giving me problems beginning of this year and I was put on losartan 50mg. I take that once a day and it seems to control my BP well (below 130/80). However, in the 4 months I've been on this medication, I've noticed when I'm on my period, my blood pressure shoot
Just felt compelled to write my positive experience with amlodipine. I've had high blood pressure for about 3-4 years. Average wasn't anything crazy, but around 150-160/90. I was prescribed 50 mg if Losartan, which seemed to do nothing. But I've been in it for the last 2 years. Finally, I decided Lo
I am a 35 year old male, recently diagnosed with stage 1 borderline stage 2 hypertension, my doc started me on 50 mg Losartan right away. I have a history of depression and anxiety and have tried Celexa, Lexapro, before finally settling in on Wellbutrin for a few years now, which has kept my normal
25m. I visited the doctor 2 months ago and was diagnosed with high bp and was put on 50mg Losartan. Was usually in the 150s/90 for the first week then it slowly worked but after my monthly visit back my doctor didn’t like the numbers so my dosage was doubled to 100mg. After 1 and a half months of lo
26m, started losartan in February and up until about 2 months ago it’s been goin great. I was exercising and eating right and doing everything i could to keep bp stead around the 120/80, when i last checked my bp about 2 months ago it was in that range.. These past 2 months I’ve been going through a
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
No community discussions found for SPIRONOLACTONE yet.
Losartan is a ARB (Angiotensin II Receptor Blocker), while SPIRONOLACTONE belongs to the Aldosterone Antagonist class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
Losartan carries 1 FDA warning. SPIRONOLACTONE carries 3 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.
Every figure on this comparison links back to its primary source. See data sources and methodology for the full provenance trail.