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Brand names: Fenofibrate, Tricor, Fenoglide
12.1 Mechanism of Action The active moiety of fenofibrate is fenofibric acid. The pharmacological effects of fenofibric acid in both animals and humans have been extensively studied through oral administration of fenofibrate. The lipid-modifying effects of fenofibric acid seen in clinical practice have been explained in vivo in transgenic mice and in vitro in human hepatocyte cultures by the activation of peroxisome proliferator activated receptor α (PPARα). Through this mechanism, fenofibrate increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III (an inhibitor of lipoprotein lipase activity). The resulting decrease in TG produces an alteration in the size and composition of LDL from small, dense particles (which are thought to be atherogenic due to their susceptibility to oxidation), to large buoyant particles. These larger particles have a greater affinity for cholesterol receptors an
Contraindications
12 documented side effects by frequency
5 Reddit threads analysed for FENOFIBRATE
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Tablets: 40, 48, 54, 120, 145, & 160mg Capsules: 43, 50, 67, 130, 134, 150, & 200mg Micronized caps: 30 & 90mg
Was reviewing a patient's medical chart. Thought to myself "Man I wonder if anyone mixed up Fenofibrate and Phenobarb". Any times when you or someone you know mixed up two sound alike drugs?
Besides the different doses offered with each formulation, does anyone know the difference between these three forms of fenofibrate? They're not interchangeable with each other either.
Has anyone seen this combination used in the retail setting? The Zetia package insert states these can be used in combination, but I was just wondering how that translates to real life.
I know we can use FDA orange book to find an approved generic substitution for certain meds with different release mechanism like diltiazem, fenofibrate. http://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/UCM071436.pdf I am been looking at the orange book and still not sure what is the b
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10 available comparisons
Dosage Forms
Tablet
Route
Oral