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Brand names: tadalafil, Cialis
12.1 Mechanism of Action Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil inhibits PDE5. Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 by tadalafil has no effect in the absence of sexual stimulation. The effect of PDE5 inhibition on cGMP concentration in the corpus cavernosum and pulmonary arteries is also observed in the smooth muscle of the prostate, the bladder and their vascular supply. The mechanism for reducing BPH sympto
Contraindications
12 documented side effects by frequency
15 Reddit threads analysed for TADALAFIL
Overall Sentiment
Mixed
Comparison Threads
1
Avg Post Score
32 upvotes
Most discussed side effects in community
Threads directly comparing TADALAFIL to other medications
So, prefacing this post with saying I can be considered an absolute newbie to pharmacy. I have a knowledge of things drug-related, and am pursuing a pharmacy degree. I happen to be confused. See my post here http://www.reddit.com/r/DrugNerds/comments/1yx92e/solubility_of_sildenafiltadalafil_for_oral
Everyone else doing tadalafil etc refills all day today? 😂 I bet half of these dudes are gonna strike out or a base hit at most 😅🤣🤣
I was picking up a shift from a rph callout for some overtime today and then a doctor sent over both nitrostat and tadalafil. I noticed that pt was on both rx for awhile and the regular staff just overrode it with no notes. Is there any valid medical reason to be on both? I’m just scratching my hea
I currently get my generic 40mg Vyvanse prescriptions from a healthcare facility that has a policy to urine drug test every quarter. This is to make sure that I'm taking the medication and not selling it. To my shock, the results from the lab showed that I tested negative for amphetamines. Is there
Not sure if anyone noticed but it looks like a couple new manufacturers started making Tadalafil tablets. Good RX now has a coupon for 30 x 5 mg for $30. It seems like overnight the price plummeted.
What do you guys think? What are you documenting if you would fill it?
The MHRA has decided to reclassify Tadalafil 10mg (as Cialis) as a P medicine. When marketed, it means it can be bought in a pharmacy without a prescription. A pharmacist is still expected to consult etc. the same as with Viagra.
Generic Cialis 20 mg (Tadalafil 20 mg by Prasco) is AB1 rated. Generic Adirca 20 mg (Tadalafil 20 mg by many manufactures) is AB2 rated. ​ In an orange book state, if the Prescriber writes for Cialis 20 mg, can you give them the generic Adirca 20 mg, given that it's AB2 Rated? &#x200
However, the patient has been on this doing well. I’m wondering if there’s a lack of data? **edit: this is a dialysis patient Thanks!
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12 available comparisons
Dosage Forms
Tablet
Route
Oral