APIXABAN vs Edoxaban

**🛎️ DING 🛎️ DING 🛎️ DING** Clinicians… **Are.**  **You.**  **Ready?** For a fight messier than ward politics… For a battle bloodier than supratherapeutic INR… For a tussle rougher than back-to-back night shifts… For the very first time, two clot-stopping heavyweights step into the ring. 

Okay, so picture this: you’re the stroke consultant. You have a patient with recurrent ischaemic stroke. You’ve *already* covered them with clopidogrel. What more can you do 🤔? Your apixaban is collecting dust because the patient doesn’t have AF.  So the PA asks “Hey, what if we gave this patient a

(I'm on inpatient neurology now...) What cause of intracranial hemorrhage is treated with tPA? >!Venous sinus thrombosis!< What drug can you use to treat migraine in pregnancy? >!Botox injections!< What is the effect of pregnancy on migraines? >!Makes migraines less severe!< The "v

Time to quiz you little nerds … who can tell me how long we treat a ***provoked*** VTE for? …Anyone?? To the trained *Passmed* monkeys who blurted “3 months!”, well done. Have a cookie 🍪 But just pause that Pavlovian hand-raise for a sec. **Why** ***three*** **months?** Why not two? or four? http

**Background:** Hi everyone! I’m a foreign pharmacy graduate from the Philippines who graduated in 2020 and moved to the US in 2021. From there I started working as a full-time hospital pharmacy technician, passed the FPGEE in 2022, completed internship hours in 2023, and recently passed the NAPLEX

Okay, so picture this: you’re the stroke consultant. You have a patient with recurrent ischaemic stroke. You’ve *already* covered them with clopidogrel. What more can you do 🤔? Your apixaban is collecting dust because the patient doesn’t have AF.  So the PA asks “Hey, what if we gave this patient a

UPDATE: I PASSED 😭😭😭😭 I took the test yesterday, and honestly, it felt pretty random. It was confusing rather than difficult. Some of the tables were hard to read or figure out. There were also a few weird management questions with vague answer choices.Time was really tight — I’d definitely reco

**Clerking the Surgical Patient** Well, it’s finally happened. You're on your first surgical on-call. You’re alone in SAU; the only point of call for every surgical nurse in the hospital. Probably the region. You’ve got someone in room one with belly pain, someone in room 2 with a wound issue, and a

Hi all. 30F, had a minor PE at 29 in May of 2025. Found it in a VQ scan they did to test for asthma after 8+ months of me complaining about extreme shortness of breath. No surgery. Unprovoked. Been on blood thinners since May 2025 (rivaroxaban), but in June/July switched to edoxaban because of extr

Any hospital pharmacists who have recently researched this topic know when the drug is going to be released? This is the much anticipated rivaroxaban/apxiaban reversal agent that has been talked about for quite some time (similar to praxbind- dabigatran’s reversal). The last I heard, last august

According to the 1/2 lives in the package insert, this doesnt really match up. Does it have more to do with protein binding? Thanks.

Does anyone know why they are dosed the way they are with regards to the lead in phase? Rivaroxaban has high dose for 21 days, Apixiban has high dose for 7 days, Edoxaban and Dabigatran both have to have a 5-10 day lead in with parenteral anticoagulation... I know "that's how the studies did it", bu

I've been on Xarelto a week. I've noticed that I get lightheaded and get a headache soon after taking each pill. I'm currently taking 15 mg twice daily. In two weeks I switch to 20 mg once a day. This has gotten worse each day. I read that the lightheadedness isn't uncommon, and saw a study that sug

Anyone else ever come across this interaction? Patient was prescribed the erythromycin for an IE of COPD. Patient was taking 60mg once daily of Lixiana (edoxaban) which is contraindicated with erythromycin here in Ireland due to CYP inhibition. They were penicillin allergic was wondering what alter