CRIZOTINIB vs LORLATINIB

**Verified?** *(This bot cannot verify AMAs just yet)* **Date:** 2013-02-21 **[Link to submission](http://www.reddit.com/r/IAmA/comments/18ymad/)** (*Has self-text*) **[Link to my post](http://www.reddit.com/r/IAmA/comments/18ymad/tabledresser/c8jk1ce)** Questions|Answers :--|:-- [Would you rather m

Hello, My husband has ROS1-positive lung cancer with multiple brain metastases. He was treated with Crizotinib, but unfortunately the brain metastases have progressed. We are considering Lorlatinib as the next treatment option, but we have concerns about availability, cost, side effects, and the app

Hi all, I have posted here before a few times about my dad (64M). He was diagnosed with NSCLC adenocarcinoma stage 4 mets to hip on December 2024. He went through 6 rounds of chemo, tumors responded (shrunk a little but still active) and was disease was considered stable. Then he was put on maintena

Hey everyone, I hoped to pose a question. The UK NHS does not use MET amplification as a biomarker for mutation testing. My father, who has Stage 4 non-small cell lung cancer, was put on the conventional treatment regimen, chemo + immunotherapy (carboplatin-pemetrexed-pembrolizumab), because nothi

Hi, I have a rare stage-IV soft tissue sarcoma with mets to the lungs and lymph nodes. Does anyone on here have any experience with crizotinib (brand name in the USA is Xalkori)? I was taking another, similar MET inhibitor (cabozantinib/Cabometyx), but I'm switching due to progression while on cabom

Hello, My husband has ROS1-positive lung cancer with multiple brain metastases. He was treated with Crizotinib, but unfortunately the brain metastases have progressed. We are considering Lorlatinib as the next treatment option, but we have concerns about availability, cost, side effects, and the app

Hey everyone, Long story short: I’m 27 and was recently diagnosed with stage 4 lung cancer ALK positive. It’s not curable, so I’ll be living with this for the rest of my life. I’m currently being treated at Memorial Sloan Kettering, and I’ll need to stay on a very specific (and very expensive) targe

HEADS UP THIS IS A LONG ONE!!! The past two years I’ve (27F) been dealing with severe breathing / wheezing problems. My PCP thought it was asthma, I was handed a pump and some montelukast. It continued and continued but I got used to it at a certain point and believed my doctor that it was just asth

Hello everyone, I’m writing as both a pulmonologist and a son. My mother has ALK-positive lung cancer, diagnosed in 2021. She has been on lorlatinib (Lorviqua) since March 2023, currently 50 mg daily, with an excellent and durable response, including complete response on recent scans. We are unfortu

I am a care partner for a 32 yr old Male who was just diagnosed with stage 4 NSCLC. Mets to liver, brain, bones (hip/spine) and lymph nodes. He got his ALK + diagnosis today and it was the first piece of ‘good news’ in weeks. His doctor has given him the option or Lorlatinib or a clinical study wher

A renowned oncologist specializing in targeted therapy and genetic treatment is now advising us to start **Lorlatinib** instead of **Lynparza** to treat my mom's (64F) pancreatic cancer with liver mets. Opposing what our current oncologist has advised us to do after we stopped chemo due to high bili

My dad has (60M) Stage IV NSCLC ALK+. Currently on Lorlatinib. It was effective for a bit but recent scans showed that the metastasized spots grew. Now, what are the alternative/ possible treatments to get it back under control? If anyone has any experience or thoughts, I would be very interested t