CRIZOTINIB vs PACRITINIB

Compare CRIZOTINIB (Xalkori) and PACRITINIB (Vonjo) — clinical data, side effects, and patient experiences.

CRIZOTINIB

Xalkori · Targeted Cancer Therapy

How it works

12.1 Mechanism of Action Crizotinib is an inhibitor of receptor tyrosine kinases including ALK, Hepatocyte Growth Factor Receptor (HGFR, c-Met), ROS1 (c-ros), and Recepteur d'Origi...

Approved for

2.1 ) • pediatric patients 1 year of age and older and young adults with relapsed or refractory

systemic anaplastic large cell lymphoma (ALCL) that is ALK-positive. ( 1.2

2.3 ) o Limitations of Use: The safety and efficacy of XALKORI have not been established in older adults with relapsed or refractory

systemic ALK-positive ALCL. • adult and pediatric patients 1 year of age and older with unresectable

OralTablet

PACRITINIB

Vonjo · Targeted Cancer Therapy

How it works

12.1 Mechanism of Action Pacritinib is an oral kinase inhibitor with activity against wild type Janus associated kinase 2 (JAK2), mutant JAK2V617F, FMS-like tyrosine kinase 3 (FLT3...

Approved for

See full prescribing information

OralTablet

Quick Comparison

CRIZOTINIBPACRITINIB

Drug Class

Targeted Cancer Therapy

Route

Oral

Half-Life

—

FDA Approved

—

Side Effect Frequency Comparison

Estimated frequency (%) based on clinical trial data

Side Effects

CRIZOTINIB

Nausea

1-10%

Diarrhea

1-10%

Vomiting

1-10%

Fatigue

0.1-1%

Peripheral Edema

0.1-1%

Constipation

0.1-1%

Shortness of Breath

0.1-1%

Decreased Appetite

0.1-1%

PACRITINIB

Diarrhea

>10%

Fatigue

>10%

Nausea

1-10%

Weakness

0.1-1%

Drug Not Working

0.1-1%

Dizziness

0.1-1%

Shortness of Breath

0.1-1%

Constipation

0.1-1%

FDA Warnings

CRIZOTINIB

5 WARNINGS AND PRECAUTIONS • Hepatotoxicity: Fatal hepatotoxicity has occurred
Advise females of reproductive potential of the potential risk to a fetus and use of effective contraception
1 Hepatotoxicity Drug-induced hepatotoxicity with fatal outcome occurred in 0
2 Interstitial Lung Disease/Pneumonitis Severe, life-threatening, or fatal interstitial lung disease (ILD)/pneumonitis can occur in patients treated with XALKORI

PACRITINIB

5 WARNINGS AND PRECAUTIONS Hemorrhage: Avoid use in patients with active bleeding and hold VONJO prior to any planned surgical procedures
Major Adverse Cardiac Events (MACE): Risk may be increased in current/past smokers and patients with other cardiovascular risk factors
Past/current smokers may be at increased risk ( 5
Risk of Infection: Delay starting VONJO until active serious infections have resolved

Community Sentiment Analysis

Based on 9 Reddit discussions

CRIZOTINIB

22%

positive

9 threads

PACRITINIB

positive

0 threads

Community-Reported Side Effects

% of discussions mentioning each side effect

Community Discussions

9 Reddit threads analysed for CRIZOTINIB

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

5 upvotes

Most discussed side effects in community

Muscle Pain (1)

Itching (1)

Patient Experiences (r/pharmacy, r/AskDocs & more)

[Table] IAmA: I am Eric Lander, a leader of the Human Genome Project and presidential advisor on science and technology.…

**Verified?** *(This bot cannot verify AMAs just yet)* **Date:** 2013-02-21 **[Link to submission](http://www.reddit.com/r/IAmA/comments/18ymad/)** (*Has self-text*) **[Link to my post](http://www.reddit.com/r/IAmA/comments/18ymad/tabledresser/c8jk1ce)** Questions|Answers :--|:-- [Would you rather m

r/tabled16013y ago

Muscle Pain

lung cancer

Hello, My husband has ROS1-positive lung cancer with multiple brain metastases. He was treated with Crizotinib, but unfortunately the brain metastases have progressed. We are considering Lorlatinib as the next treatment option, but we have concerns about availability, cost, side effects, and the app

r/lungcancer933mo ago

Crizotinib (questions)

Hi all, I have posted here before a few times about my dad (64M). He was diagnosed with NSCLC adenocarcinoma stage 4 mets to hip on December 2024. He went through 6 rounds of chemo, tumors responded (shrunk a little but still active) and was disease was considered stable. Then he was put on maintena

r/lungcancer722mo ago

NSCLC - MET Amplification +

Hey everyone, I hoped to pose a question. The UK NHS does not use MET amplification as a biomarker for mutation testing. My father, who has Stage 4 non-small cell lung cancer, was put on the conventional treatment regimen, chemo + immunotherapy (carboplatin-pemetrexed-pembrolizumab), because nothi

r/lungcancer672y ago

Experiences with crizotinib / Xalkori?

Hi, I have a rare stage-IV soft tissue sarcoma with mets to the lungs and lymph nodes. Does anyone on here have any experience with crizotinib (brand name in the USA is Xalkori)? I was taking another, similar MET inhibitor (cabozantinib/Cabometyx), but I'm switching due to progression while on cabom

r/cancer485y ago

Itching

Crizotinib for c-MET–amplified advanced NSCLC: a single-center experience

r/nsclc205y ago

Real-world studies of crizotinib in patients with ROS1-positive non-small-cell lung cancer: experience from China

r/LungCancerSupport101y ago

lung cancer

r/LungCancerSupport133mo ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Community Discussions

No community discussions found for PACRITINIB yet.